- Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization
-
Reliable regio- and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive due to the challenges of discriminating between multiple, relatively strong sp3 C-H bonds whose chemical behavior often differ onl
- Munnuri, Sailu,Adebesin, Adeniyi Michael,Paudyal, Mahesh P.,Yousufuddin, Muhammed,Dalipe, Alfonso,Falck, John R.
-
supporting information
p. 18288 - 18294
(2017/12/27)
-
- HETEROCYCLIC COMPOUND DERIVATIVES AND MEDICINES
-
The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (R1 and R2 are the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR5, O, S, or ethylene, R5 represents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH2, R3 and R4 are the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.
- -
-
-
- Diastereoselective Synthesis of Cis-3- And 3,5-Alkylpyrrolizidines
-
Cis-3 and 3,5-substituted pyrrolizidines can be prepared from β-enaminolactones. Substituted pyrrolidinoketones lead to these compounds by an amino reductive annelation with a low diastereomeric excess, but a best access to these azabicycles consists in preparing cis-2,5-disubstituted pyrrolidines which are then transformed into the expected heterocycles.
- Provot, Olivier,Celerier, Jean-Pierre,Lhommet, Gerard
-
p. 371 - 376
(2007/10/03)
-
- Synthesis and Kinetics of the Formation of N-Substituted Cyclic Sulfinamides from Secondary Amine Disulfides
-
N-substituted cyclic saturated sulfinamides were prepared from two secondary amine disulfides, 3-propyl disulfide and 3-(cyclohexylamino)propyl disulfide, and two bicyclic sulfinamides were made from 2-(2-piperidyl)ethyl disulfide an
- Wagner, Barbara J.,Doi, Joyce Takahashi,Musker, W. Kenneth
-
p. 4156 - 4162
(2007/10/02)
-