- Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant
-
The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.
- Chu, Benfa,Fang, Lili,Guo, Shan,Qi, Bing,Shi, Pengfei,Wang, Qi,Zhu, Jin
-
-
- A Mechanochemical-Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles
-
A mild, efficient, metal- and solvent-free oxidation of primary amines to aldehydes, ketones, and nitriles under ball-milling conditions is presented. This method has proved to be compatible with various functional groups and only requires easily accessible starting materials. Simple purification of the reaction mixtures by short-column chromatography afforded pure aldehydes, ketones, and nitriles as products.
- Gaspa, Silvia,Porcheddu, Andrea,Valentoni, Antonio,Garroni, Sebastiano,Enzo, Stefano,De Luca, Lidia
-
p. 5519 - 5526
(2017/09/06)
-
- An insight of the reactions of amines with trichloroisocyanuric acid
-
The reaction between amines or α-aminoacids with trichloroisocyanuric acid is studied under various conditions: N,N-dichloroamines, nitriles and ketones can be obtained from primary amines, while free aminoacids undergo oxidative decarboxylation to the corresponding nitrile of one less carbon atom.
- De Luca, Lidia,Giacomelli, Giampaolo
-
p. 2180 - 2184
(2007/10/03)
-
- Preparations of (Alkylideneamino)sulfonium Salts, Thioxime S-Alkyl Ethers, and of (Alkylideneamino) Thiocyanates
-
Stable (alkylideneamino)sulfonium salts (1a - u) are obtained from α-halogen isocyanates (12) by reaction with sulfoxides (13), from the reaction of N-chloroimines (14) with sulfides (15), or by alkylation of N-alkylidenesulfenamides (16) with trimethylox
- Reck, Reinhard,Jochims, Johannes C.
-
p. 1494 - 1508
(2007/10/02)
-