- INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR
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Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.
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- Preparation method of nilaparib intermediate
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The preparation method comprises the following steps: in a reaction solvent, a compound 1 and a compound 2 are reacted under the synergistic catalysis of a photocatalyst and Ni catalyst to obtain compound 3, and compound 3 is a nilaparib intermediate. Whe
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Paragraph 0045-0059
(2021/10/05)
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- Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes
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(Chemical Equation Presented) Conversion of ester moieties into 4-bromophenyl groups was effected by means of a four-step protocol: a Grignard reaction of the ester with allylmagnesium halides, a ring-closing metathesis, dibromocyclopropanation, and an electrocyclic reaction of the dibromocyclopropanes.
- Ueda, Kyosuke,Umihara, Hirotatsu,Yokoshima, Satoshi,Fukuyama, Tohru
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supporting information
p. 3191 - 3193
(2015/07/15)
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- TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME
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Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
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- 2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES
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A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.
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Page 289-290
(2008/06/13)
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