Phenyliodine(III) Diacetate/I2-Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4-Thiazines by a One-Pot Morin Rearrangement of N,S-Acetals
An efficient domino transformation using a phenyliodine(III) diacetate (PIDA)/I2 combination towards Morin 1,4-thiazine compounds has been developed starting from N,S-acetals. The latter leads to “one-step” regioselective methylene insertion without the need for traditional sulfoxide intermediates in good yields. The reaction involves easily accessible N,S-acetals obtained from cost-effective basic ketones and cysteamine as starting materials. This process ultimately leads to 1,4-thiazines related to natural product and fused derivatives necessary for further QSAR study.
Danton, Fanny,Othman, Mohamed,Lawson, Ata Martin,Moncol, Ján,Ghinet, Alina,Rigo, Beno?t,Da?ch, Adam
p. 6113 - 6118
(2019/04/17)
Comparative radioprotective activity of various pentagonal compounds with two heteroatomes
Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.
Robbe,Fernandez,Dubief,et al.
p. 235 - 243
(2007/10/02)
2-Phenyl thiazolidine derivatives as radioprotective agents
31 derivatives of 2-phenyl thiazolidine were submitted to radio-pharmacological tests on mice. They usually present little toxicity and some of them show a rather interesting activity.
Terol,Fernandez,Robbe,et al.
p. 149 - 151
(2007/10/04)
Schiff bases. II. Some ketimines prepared by decarboxylation of alpha-amino-acids in the presence of ketones and their reaction and that of aldimines with phenyl lsocyanate.