- Reductive cyclizations of nitroarenes to hydroxamic acids by visible light photoredox catalysis
-
We have developed a photocatalytic reduction of nitroarenes as an efficient, chemoselective route to biologically important N-phenyl hydroxamic acid scaffolds. Optimal conditions call for 2.5 mol% of a ruthenium photocatalyst, visible light irradiation, and a dihydropyridine terminal reductant. Because of the mild nature of the visible light activation, functional groups that might be sensitive to other non-photochemical reduction methods are easily tolerated. Georg Thieme Verlag Stuttgart New York.
- Cismesia, Megan A.,Ischay, Michael A.,Yoon, Tehshik P.
-
p. 2699 - 2705
(2013/10/21)
-
- Tungstate-Catalyzed Oxidation of Tetrahydroquinolines with Hydrogen Peroxide: A Novel Method for the Synthesis of Cyclic Hydroxamic Acids
-
The sodium tungstate catalyzed oxidation of 1,2,3,4-tetrahydroquinolines (1) with 30percent aqueous hydrogen peroxide solution in methanol gives 1-hydroxy-3,4-dihydroquinolin-2(1H)-ones (2), which are important biologically active compounds, in good to excellent yields.The cyclic hydroxamic acid 7 is also obtained in good yield.Since reduction of 2 thus obtained gives 3,4-dihydroquinolin-2(1H)-ones (4), the present reaction provides a convenient method for synthesis of 4 from 1.
- Murahashi, Shun-Ichi,Oda, Tetsuya,Sugahara, Toshiaki,Masui, Yoshiyuki
-
p. 1744 - 1749
(2007/10/02)
-