- Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties
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The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dimethyl-1H-pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests.
- Rodriguez-Franco, Maria Isabel,Dorronsoro, Isabel,Martinez, Ana,Perez, Concepcion,Badia, Albert,Banos, Josep E.
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p. 118 - 122
(2007/10/03)
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- 1,2,3-Triazines,III. - Synthesis of N-Aminopyrazoles and their Oxidation to 1,2,3-Triazines. Molecular Structure of 1,2,3-Triazine
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Oxidation of the N-aminopyrazoles 4a-i affords the 1,2,3-triazines 5a-i.Spectra and reactions - such as oxidation, reduction, and cycloaddition reactions - of some 1,2,3-triazines 5 are described.The X-ray analysis of 5a is presented.
- Neunhoeffer, Hans,Clausen, Monika,Voetter, Hans-Dieter,Ohl, Harald,Krueger, Carl,Angermund, K.
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p. 1732 - 1751
(2007/10/02)
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- Oxidation of 1-Aminopyrazoles and Synthesis of 1,2,3-Triazines
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Unsubstituted and various substituted monocyclic 1,2,3-triazines were synthesized from 1-aminopyrazoles by oxidation with lead tetraacetate, lead dioxide-CF3CO2H, and/or nickel peroxide-AcOH.
- Ohsawa, Akio,Arai, Heihachiro,Ohnishi, Hidefumi,Itoh, Takashi,Kaihoh, Terumitsu,et al.
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p. 5520 - 5523
(2007/10/02)
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