- Synthesis of Cystine Peptides with a Primary Structure Related to the Active Region of Insulin
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The synthesis of the unsymmetrical disulfide 1 , a section of the active insulin region, is described.Starting from this material, stepwise simplification of the primary structure was performed by preparing the disulfides B 15-27 (Ala 27)-A 20-21, B 15-20-A 19-21, B 15-27 (SEt 19, Ala 27), and 2 (2-5).The corresponding disulfide bonds were established by proton catalysed disulfide exchange between the two partial components containing SEt-protected cysteine functions.The synthesized cystine peptides exhibit distinct but by the factor of 10-3 to 10-4 reduced insulin activities.
- Losse, Guenter,Stange, Hans,Naumann, Wolfgang
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p. 143 - 151
(2007/10/02)
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