- Preparation method for 2, 3-difluoro-6-methoxy benzoic acid
-
The invention provides a preparation method for 2, 3-difluoro-6-methoxy benzoic acid. The preparation method includes the steps: (1) preparing tetrahydrofuran solution of lithium diisopropylamide; (2) reducing temperature to range from -75 DEG C to -65 DE
- -
-
Paragraph 0030; 0033-0036; 0039-0042; 0045-0048; 0051-0054
(2017/02/28)
-
- Method for preparing 2,3-difluoro-6-methoxybenzoic acid
-
The invention discloses a method for preparing 2,3-difluoro-6-methoxybenzoic acid. The method includes the steps that an aqueous solution with potassium hydroxide dissolved therein is added into compound 2,3-difluoro-6-methoxy-benzaldehyde, hydrogen perox
- -
-
Paragraph 0014; 0015; 0016
(2017/01/31)
-
- PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S
-
The invention provides compounds of the formula (I), or salts, tautomers, N-oxides or solvates thereof wherein: R1 is selected from: (a) 2,6-dichlorophenyl; (b) 2,6-difluorophenyl; (c) a 2,3,6-trisubstituted phenyl group wherein the substituents for the phenyl group are selected from fluorine, chlorine, methyl and methoxy; (d) a group R0; (e) a group R a; (f) a group Rlb; (g) a group Rlc; (h) a group Rld; and 0) 2,6-difluorophenylamino ; wherein R )0υ, r R> llaa, T Rj I1bD, T R) I1cC, r R> Iidα, r R?2zaa, r R>22bD and RJ are as defined in the claims. The compounds have activity as inhibitors of cdk kinase (such as cdkl or cdk2) and glycogen synthase kinase-3 activity.
- -
-
Page/Page column 148
(2008/06/13)
-