- Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles
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Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is
- Zhang, Lei,Chen, Junyu,Chen, Xiahe,Zheng, Xiangyun,Zhou, Jian,Zhong, Tianshuo,Chen, Zhiwei,Yang, Yun-Fang,Jiang, Xinpeng,She, Yuan-Bin,Yu, Chuanming
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p. 7415 - 7418
(2020/07/15)
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- Expeditious synthesis of multisubstituted indoles: Via multiple hydrogen transfers
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Described herein is the expeditious construction of multi-substituted indole skeletons via multiple hydrogen transfers. When ortho-amino ketoesters were treated with a catalytic amount of TiCl4 in the presence of 1.0 equivalent of dehydrating reagent, three types of hydrogen transfer processes ([1,5]-hydride shift, proton transfer, and [1,2]-hydride shift) occurred to give various 3-alkoxycarbonylindoles. Further study revealed that a [1,2]-alkyl shift instead of a [1,2]-hydride shift proceeded to afford 3-alkylindoles from the substrates with an amino group having tertiary carbons adjacent to a nitrogen atom.
- Yoshida, Taira,Mori, Keiji
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p. 12686 - 12689
(2018/11/23)
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- Synthesis of diversely substituted indoloquinolinones via Pd(II)/Cu(II)-mediated oxidative C-C bond formation and I(III)-mediated C-N bond formation
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A series of indoloquinolinones bearing different aromatic substitutents were readily synthesized starting from an aryl amine, a methyl 3-oxo-3-phenylpropanoate derivative, and methoxylamine through a series of reactions of coupling/enamination, oxidative
- Zhang, Xiang,Zhang-Negrerie, Daisy,Deng, Jun,Du, Yunfei,Zhao, Kang
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p. 12750 - 12759
(2014/01/17)
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- Fluorescent diarylindoles by palladium-catalyzed direct and decarboxylative arylations of carboxyindoles
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A study was conducted to demonstrate the palladium-catalyzed 2,3-diarylation of carboxyindole derivatives with acryl bromides. The study also performed ester hydrolysis in the sequence to demonstrate a practical route to 2,3-diarylindoles that had differe
- Miyasaka, Mitsuru,Fukushima, Azusa,Satoh, Tetsuya,Hirano, Koji,Miura, Masahiro
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supporting information; experimental part
p. 3674 - 3677
(2009/12/25)
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