- Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
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Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subg
- Ontoria, Jesus M.,Martin Hernando, Jose I.,Malancona, Savina,Attenni, Barbara,Stansfield, Ian,Conte, Immacolata,Ercolani, Caterina,Habermann, Joerg,Ponzi, Simona,Di Filippo, Marcello,Koch, Uwe,Rowley, Michael,Narjes, Frank
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p. 4026 - 4030
(2007/10/03)
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- INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE
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The present invention relates to indole and azaindole compounds of formula (I): wherein X1, X2, X3, X4, A1, Ar1, R1, R2 and n are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
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