TANDEM-CONJUGATE ADDITION-α-ADDITION OF UNSATURATED AMIDES. SYNTHETIC METHODOLOGY.
1,4-Addition of RLi, RMgX, and (RS)2CHLi reagents to unsaturated amides 2a-c followed by α-alkylation is shown to constitute a general and efficient synthetic procedure for the formation of two C-C bonds in a single step.
Mpango, G. B.,Mahalanabis, K. K.,Mahdavi-Damghani, Z.,Snieckus, V.
p. 4823 - 4826
(2007/10/02)
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