- Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: Synthesis, 1H and 13C NMR conformational studies, and antiviral and cytostatic evaluations
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The synthetic route for introduction of a fluoroalkyl (7-12,14), fluoroalkenyl (15 and 16), fluorophenylalkyl (17, 19, 20, and 22), and fluorophenylalkenyl (18, 21) side chain at C-6 of the pyrimidine involved the lithiation of the pyrimidine derivatives
- Prekupec, Svjetlana,Makuc, Damjan,Plavec, Janez,?uman, Lidija,Kralj, Marijeta,Paveli?, Kre?imir,Balzarini, Jan,De Clercq, Erik,Mintas, Mladen,Rai?-Mali?, Silvana
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- Bromination of pyrimidines: A simple inexpensive method
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Although the introduction of halogens into the pyrimidine ring has been accomplished numerous times, the methods usually involve either specialised reagents or very aggressive conditions. This communication paper describes the introduction of bromine into position 5 of the pyrimidine ring using common inorganic salts at room temperature. An evaluation of the substituents required for successful reaction is provided.
- Delia, Thomas J.,Hood, Robin J.
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p. 254 - 255
(2015/02/19)
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- Synthesis, structural studies and antitumoral evaluation of C-6 alkyl and alkenyl side chain pyrimidine derivatives
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The synthetic route for introduction of fluorophenylalkyl (compounds 5, 7, 14 and 15) and fluorophenylalkenyl (compounds 4E and 13) side chains at C-6 of the pyrimidine nucleus involved the lithiation of the pyrimidine derivatives 1, 2 and 11 and subseque
- Kristafor, Svjetlana,Kraljevic, Tatjana Gazivoda,Makuc, Damjan,Plavec, Janez,Suman, Lidija,Kralj, Marijeta,Raic-Malic, Silvana
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p. 4866 - 4879
(2010/04/05)
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