- Symmetrical diaza disulfide compound as well as synthesis method and application thereof
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The invention discloses a formula (1). The method comprises the following steps: reacting the compound represented by the formula (2), the formula (3) and the formula (4 6 5) with dichloro disulfide as a reaction raw material, and reacting under the action of a base to obtain the symmetrical disulfide compound. The method has the advantages of mild reaction conditions, cheap and accessible raw materials, simple reaction operation and high yield. The reaction substrate is easy to prepare. The reaction is an amplification reaction. The reaction of the present invention can be used to construct novel polysulfide compounds.
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Paragraph 0087-0090
(2021/10/27)
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- A Unified Strategy for Arylsulfur(VI) Fluorides from Aryl Halides: Access to Ar-SOF3 Compounds
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A convenient protocol to selectively access various arylsulfur(VI) fluorides from commercially available aryl halides in a divergent fashion is presented. Firstly, a novel sulfenylation reaction with the electrophilic N-(chlorothio)phthalimide (Cl-S-Phth) and arylzinc reagents afforded the corresponding Ar-S-Phth compounds. Subsequently, the S(II) atom was selectively oxidized to distinct fluorinated sulfur(VI) compounds under mild conditions. Slight modifications on the oxidation protocol permit the chemoselective installation of 1, 3, or 4 fluorine atoms at the S(VI) center, affording the corresponding Ar-SO2F, Ar-SOF3, and Ar-SF4Cl. Of notice, this strategy enables the effective introduction of the rare and underexplored -SOF3 moiety into various (hetero)aryl groups. Reactivity studies demonstrate that such elusive Ar-SOF3 can be utilized as a linchpin for the synthesis of highly coveted aryl sulfonimidoyl fluorides (Ar-SO(NR)F).
- Cornella, Josep,Wang, Lin
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supporting information
p. 23510 - 23515
(2020/10/29)
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- N-Alkynylthio Phthalimide: A Shelf-Stable Alkynylthio Transfer Reagent for the Synthesis of Alkynyl Thioethers
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A new kind of electrophilic alkynylthiolating reagent, called N-alkynylthio phthalimide, is designed and synthesized herein. This electrophilic sulfenylating reagent can be easily prepared in three steps from commercially available phthalimide and corresp
- Gao, Wen-Chao,Shang, Yu-Zhu,Chang, Hong-Hong,Li, Xing,Wei, Wen-Long,Yu, Xin-Zhang,Zhou, Rong
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supporting information
p. 6021 - 6024
(2019/08/20)
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- An internal oxidant-directing strategy enabling transition metal-free C–S bond ligation
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Organic sulfur compounds have broad applications in biology, medicine and material sciences and intensive efforts have been devoted to developing mild and general C–S bond-forming methods. However, a mild, transition-metal-free, direct C–H bond functionalization method remains elusive. Here, we report the use of an internal oxidant-directing strategy to achieve this goal. The cascade reactions described here show excellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation reagents. This study enlarges the synthesis toolbox for preparing structurally diverse sulfilimines under mild conditions.
- Zuo, Yingying,Xiong, Feng,Zhao, Jing
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supporting information
p. 4174 - 4179
(2019/05/24)
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- BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY
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The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.
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- N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation
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A new, electrophilic difluoromethylthiolating reagent N-difluoromethylthiophthalimide 3 was developed. Reagent 3 can be readily synthesized in four steps from easily available starting materials phthalimide and TMSCF2H. N-difluoromethylthiophthalimide 3 is a powerful electrophilic difluoromethylthiolating reagent that allows the difluoromethylthiolation of a wide range of nucleophiles including aryl/vinyl boronic acids, alkynes, amines, thiols, β-ketoesters, and oxindoles and electron-rich heteroarenes such as indole, pyrrole, 1H-pyrrolo[2,3-b]pyridine, imidazo[1,2-a]pyridine, aminothiazole, isoxazole, and pyrazole under mild conditions.
- Zhu, Dianhu,Gu, Yang,Lu, Long,Shen, Qilong
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supporting information
p. 10547 - 10553
(2015/09/28)
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- HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
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Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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Page/Page column 71; 72
(2013/08/28)
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- New polymers possessing a disulfide bond in a unique environment
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The synthesis and some of the physical properties of the first poly(disulfidediamines) are reported. The disulfidediamine functional group (R2NSSNR2) possesses a disulfide bond in a unique environment that leads to a low bond dissociation energy (calculated BDE of 43.1 kcal mol-1). These polymers were synthesized in high yields and with conversions up to >98% by reactions between secondary diamines and a new disulfide monomer. The disulfide monomer was synthesized in two steps without the need for column chromatography. The polymerizations were robust and completed at room temperature, under ambient atmospheric conditions, and in solvents that were used as purchased. These polymers were stable, but they rapidly decomposed under acidic, aqueous conditions or by heating to 175 °C as shown by thermal gravimetric analysis. The first fully conjugated poly(disulfidediamine) was synthesized, and its electrical conductivity was characterized in the solid state.
- Graf, Tyler A.,Yoo, Jun,Brummett, Adam B.,Lin, Ran,Wohlgenannt, Markus,Quinn, Daniel,Bowden, Ned B.
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p. 8193 - 8200
(2013/01/15)
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- New potent and selective A1 adenosine receptor agonists
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Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A1 adenosine receptor agonists. Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A1 adenosin
- Hutchinson, Sally A.,Baker, Stephen P.,Linden, Joel,Scammells, Peter J.
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p. 4877 - 4884
(2007/10/03)
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- Reactions of hexamethylditin and trimethyltin sulfide with N-thio-derivatives of phthalimide
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The initial formation of organotin derivatives with Sn-S-N bonds in heterolytic reactions of hexamethylditin or trimethyltin sulfide with N-(chlorothio)phthalimide is suggested.Subsequent interaction of these compounds with sulfenyl chloride affords N,N'-thio- or N,N'-dithiobisphthalimide.Homolytic reaction of hexamethylditin with N,N'-dithiobisphthalimide also occurs via an organotin intermediate, which, in the absence of a nucleophilic reagent, eliminates sulfur and converts into N-trimethylstannylphthalimide. - Key words: hexamethylditin; trimethyltin sulfide; N-(chlorothio)phthalimide; N,N'-dithiobisphthalimide; reactivity.
- Shcherbakov, V. I.,Grigor'eva, I. K.
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p. 2025 - 2028
(2007/10/02)
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- Thiation reactions of some active carbonyl compounds with sulfur transfer reagents
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Anthrone reacts with the sulfur transfer reagents dithiobisphthalimide and dithiobissuccinimide in the presence of pyridine to provide a simple synthesis of monothioanthraquinone. Products of a different nature, derived from two molecules of ketone, were obtained from acenaphthenone and from a variety of β-diketones. A unified mechanism for the formation of all of the observed products, based upon the generation of transient thione intermediates, is proposed and supported by trapping experiments.
- Huang, Nai-Zhong,Lakshmikantham,Cava, Michael P.
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p. 169 - 172
(2007/10/02)
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