- A 3 - bromo -4 - fluoro benzaldehyde synthetic method
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The present invention relates to the technical field of agricultural chemicals or pharmaceutical intermediate synthesis, in particular to a 3 - bromo - 4 - fluoro benzaldehyde synthetic method, comprises the following steps: (1) the 4 - fluorophenyl formaldehyde dissolved in methylene chloride, to obtain solution A; (2) the sodium bromide is dissolved in pure water, stirring while adding 35% hydrochloric acid, to obtain solution B; (3) the solution and the solution after mixing A B, opening ultrasonic, dropping sodium hypochlorite aqueous solution; (4) [...], ultrasonic, thermal insulation under stirring, then standing; (5) split-phase, dichloromethane phase washed to neutral, drying desolvation; (6) it is crude, 31 °C body melt crystallization, to get the pure product. The synthetic method does not require the use of a catalyst, in the process does not involve the precursor chemicals or toxic chlorine bromine; raw materials are easy, low-risk; high yield; process green, easy operation, and environmental protection.
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Paragraph 0024-0050
(2019/07/05)
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- Copper-Catalyzed Oxidative Difunctionalization of Terminal Unactivated Alkenes
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The copper(II)-promoted free-radical oxidative difunctionalization of terminal alkenes to access ketoazides by utilizing molecular oxygen has been reported. A series of styrene derivatives have been evaluated and were found to be compatible to give the desired difunctionalized products in moderate to good yields. The role of molecular oxygen both as an oxidant and oxygen atom source in this catalytic transformation has been unquestionably demonstrated by 18O-labeling studies and a radical mechanistic pathway involving the oxidative formation of azidyl radicals is also designed. This environment-friendly catalytic oxidative protocol can transform aldehyde to nitrile.
- Hussain, Muhammad Ijaz,Feng, Yangyang,Hu, Liangzhen,Deng, Qingfu,Zhang, Xiaohui,Xiong, Yan
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supporting information
p. 7852 - 7859
(2018/05/30)
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- PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols
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A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.
- Fujimoto, Teppei,Ritter, Tobias
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supporting information
p. 544 - 547
(2015/03/05)
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- PROCESS FOR THE PREPARATION OF 3-BROMO - 4 - FLUOROBENZALDEHYDE
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The invention relates to a process of manufacturing 3-bromo-4- fluorobenzaldehyde using zinc bromide as a catalyst.
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Page/Page column 11-12
(2010/08/09)
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- Solvent-free oxidation of alcohols with potassium persulphate in the presence of bronsted acidic ionic liquids
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An efficient conversion of alcohols to aldehydes was achieved using potassium persulphate and 3-methylimidazolinium methane sulfonate. Copyright Taylor & Francis Group, LLC.
- Chaskar,Bhandari,Patil,Sharma,Mayeker
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experimental part
p. 366 - 370
(2009/04/07)
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- Isoquinoline compound melanocortin receptor ligands and methods of using same
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The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands and as agents for controlling cytokine-regulated physiologic processes and pathologies, and combinatorial libraries thereof.
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- Insecticidal ethers
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This invention relates to novel fluorinated ethers, useful as insecticides and acaricides, to processes and intermediates for their preparation, to insecticidal and acaricidal compositions thereof and to methods of combating and controlling insect and acarine pests therewith.
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- Fluorobenzyl esters
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A compound of formula: STR1 wherein R is selected from hydrogen, cyano, methyl, and ethynyl, and X represents the residue of any carboxylic acid of formula X-COOH which forms an insecticidally active ester with a 3-phenoxybenzyl alcohol. The compounds are useful as insecticides and acaricides.
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- Insecticidal alkenes
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A compound of formula: wherein X and Y are each selected from hydrogen and halogen, R1 and R2 are each lower alkyl of up to four carbon atoms, or together with the adjacent carbon atom form a cycloalkyl group of up to six carbon atoms, and R represents a phenoxy- or benzyl-substituted phenyl group which may optionally be substituted with fluorine. The compounds are useful for combating insect pests.
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- Pyrimidine derivatives
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A compound of formula: STR1 wherein R1 represents hydrogen or halogen, R2 represents an α-branched alkyl or a cycloalkyl group containing from 3 to 6 carbon atoms, Q represents hydroxy, halo, alkoxy of up to 6 carbon atoms or a group --OR where R represents the residue of an alcohol of formula ROH which forms an insecticidal ester when combined with crysanthemic acid, or 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, or 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid. The compounds are useful for combating insect and acarime pests.
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- Diphenyl ether derivatives and their use as insecticides
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A compound of formula: STR1 wherein W represents one or more substituents selected from halo, alkyl, alkoxy, alkoxyalkyl, haloalkyl and haloalkoxy or W represents a bidentate group linking adjacent carbon atoms selected from alkylene and alkylenedioxy; Y is a group of formula STR2 wherein X is a group of formula --(CF2)n R3, where R3 is selected from hydrogen, chloro and fluoro, and n is one or two, R1 is selected from hydrogen, chloro, fluoro and hydroxy and R2 is selected from methyl, cyano, ethynyl and hydrogen; Q is selected from carbon bearing a hydrogen atom and nitrogen; and Z represents one or more substituents selected from fluoro, benzyl, phenoxy, chlorophenoxy, fluorophenoxy and bromophenoxy, or any isomer thereof. Processes for preparing these compounds and intermediates for use therein, insecticidal compositions containing these compounds and the use thereof are also disclosed.
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- Insecticidal ethers
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Insecticidally active compounds of the formula (I): STR1 wherein R4 represents a group selected from those groups represented by R5 in insecticidally active compounds of formula: STR2 R3 is selected from fluoromethyl and difluoromethyl, and either (a) R1 and R2 represent alkyl of one, two, three or four carbon atoms, or (b) R1 and R2 taken together with the adjacent carbon atom form a cycloalkyl ring of four, five or six carbon atoms.
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- Preparation of 4-fluoro-3-phenoxy-benzal-dehyde acetals and intermediates therefor
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The new compound STR1 is prepared and converted to the new acetal STR2 which is reacted with an alkali phenolate or alkaline earth metal phenolate in the presence of copper or a copper compound as a catalyst and in the presence of a diluent at a temperature between about 100° and 200° C. to produce the new acetal STR3 which can be hydrolyzed to the corresponding aldehyde which is a known intermediate for pyrethroid-like insecticides.
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- Preparation of 3-bromo-4-fluorobenzaldehyde and its acetals
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A process for the preparation of a 3-bromo-4-fluorobenzaldehyde acetal of the formula STR1 in which R1 is methyl or ethyl, which comprises reacting a 3-bromo-4-fluoro-benzoic acid halide with ammonia to form 3-bromo-4-fluoro-benzoic acid amide, dehydrating said amide to form 3-bromo-4-fluoro-benzonitrile, reacting the nitrile with formic acid in the presence of a catalyst at a temperature between about 0° and 150° C. to form 3-bromo-4-fluorobenzaldehyde, and reacting said aldehyde with R1 OH or a derivative thereof capable of forming an acetal. The amide and nitrile are new compounds. The acetals are known intermediates in the synthesis of pyrethroid-like insecticides.
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