Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors
We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxym
Powell, Noel A.,Clay, Emma H.,Holsworth, Daniel D.,Bryant, John W.,Ryan, Michael J.,Jalaie, Mehran,Zhang, Erli,Edmunds, Jeremy J.
p. 2371 - 2374
(2007/10/03)
PIPERAZINE DERIVATIVE RENIN INHIBITORS
Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):
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Page 137-138
(2010/02/09)
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