Regio- and enantioselectivity of the enzyme-catalyzed hydrolysis of citric acid derivatives
The hydrolysis of triethyl citrate in the presence of three serine proteases (chymotrypsin, subtilisin BPN', subtilisin carlsberg) is highly regioselective and gives the symmetric diester. Several lipases and proteases have the complementary regioselectivity and give the chiral diester. Pig liver esterase, Aspergillus niger lipase and Candida antarctica lipase give the chiral (R)-diester with good regio- and enantioselectivity. The stereoselective hydrolysis of the meso citric derivatives 7a,b in the presence of Candida antarctica lipase gives the corresponding (R)-monoester.
Chenevert, Robert,Tchedam Ngatcha, Beatrice,Yannick, Stephane Rose,Goupil, Daniel
p. 4325 - 4329
(2007/10/03)
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