- An approach to discovering novel exciplex supramolecular complex based on carbazole-containing 1,8-naphthalimide
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A new luminescent ambipolar semiconductor consisting of 1,8-naphthalimide as an electron-accepting moiety and carbazole as an electron-donating moiety has been synthesized and characterized. The synthesized compound as ambipolar semiconductor has been investigated by using density functional theory calculations coupled with the charge-hopping model and the time-of-flight experimental method. The time-of-flight hole and electron drift mobilities in the synthesized material's layer approached about 10?4 cm2 V?1 s?1 at high electric fields. The exciplex complex is stabilized by the intermolecular hydrogen bond and electron donor-acceptor interactions. The energy of interactions between the molecules in the exciplex complex has been estimated to be about ?100 kJ mol?1 by DFT. Non-doped emissive layer organic light-emitting diode (OLED) using the synthesized compound as an emitter exhibited an orange color emission with the Commission International de L'Eclairage chromaticity coordinates of (0.47, 0.49).
- Bezuglyi, Mykola,Ivaniuk, Khrystyna,Volyniuk, Dmytro,Gra?ulevi?ius, Juozas V.,Bagd?iūnas, Gintautas
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Read Online
- Kinetics of N-oxyl Radicals' Decay
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N-oxyl radicals of various structures were generated by oxidation of corresponding N-hydroxy compounds with iodobenzene diacetate, [bis(trifluoroacetoxy)]iodobenzene, and ammonium cerium(IV) nitrate in acetonitrile. The decay rate of N-oxyl radicals follows first-order kinetics and depends on the structure of N-oxyl radicals, reaction conditions, and the nature of the solvent and oxidant. The values of the self-decay constants change within 1.4 × 10-4 s-1 for the 3,4,5,6-tetraphenylphthalimide-N-oxyl radical to 1.4 × 10-2 s-1 for the 1-benzotriazole-N-oxyl radical. It was shown that the rate constants of the phthalimide-N-oxyl radicalsê? self-decay with different electron-withdrawing or-donor substituents in the benzene ring are higher than that of the unsubstituted phthalimide-N-oxyl radical in most cases. The solvent effect on the process of phthalimide-N-oxyl radical self-decomposition was investigated. The dependence of the rate constants on the Gutmann donor numbers was shown.
- Hordieieva, Iryna,Kompanets, Mykhailo,Kushch, Olga,Litvinov, Yurii,Novikova, Katerina,Opeida, Iosip,Shendrik, Alexander
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p. 7112 - 7124
(2020/07/07)
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- A cinnamic acid naphthalene dicarboxylic acid imide ester compound and use thereof
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The invention discloses naphthalene cinnamate dicarboximide ester compounds which have a structure as shown in a formula I; the compounds can be used as a plant growth regulator. The compounds as shown in the formula I have excellent functions of promoting germination, rooting as well as production-increasing and quality-improving, has a good bactericidal effect, and has control effects especially for phytophthora capsici, wheat scab, apple ring spot and cucumber blight disease at 200ppm, and the like, thus being widely used for disease prevention and yield improvement in agriculture or forestry. The formula I is described in the description.
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Paragraph 0017; 0021-0023
(2019/07/04)
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- Metal-Free Synthesis of Adipic Acid via Organocatalytic Direct Oxidation of Cyclohexane under Ambient Temperature and Pressure
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A direct metal-free approach for the production of adipic acid from cyclohexane is reported. The use of N-hydroxyphthalimide (NHPI) as a catalyst in the presence of HNO3/TFA enables the direct oxidation of cyclohexane to yield adipic acid under ambient temperature and pressure via a simple procedure. This reaction proceeds through an initial oxidation of cyclohexane to cyclohexanone oxime and cyclohexanone followed by a second oxidation of these intermediates to adipic acid. NHPI plays a crucial role in both oxidation steps to achieve a high yield and selectivity for adipic acid.
- Matsumoto, Yohei,Kuriyama, Masami,Yamamoto, Kosuke,Nishida, Koyo,Onomura, Osamu
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supporting information
p. 1312 - 1317
(2018/09/25)
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- Imide bit or 4 - substituted 1, 8 - naphthalene imide derivatives as PARP inhibitors
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The invention belongs to the field of medical chemistry, discloses use of imide site or 4-substituted 1, 8-naphthyl imide derivatives as PARP (poly adeno-sine diphosphate ribose polymerase) inhibitors, and in particular relates to the use of 1, 8-naphthyl imide derivative as shown in general formula (I), pharmacological or physiologically acceptable salts of the compound as shown in the general formula (I), and pharmaceutical compositions of the compound as shown in the general formula (I), as the PARP (poly adeno-sine diphosphate ribose polymerase) inhibitors. R1 and R2 have the meanings as defined.
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Paragraph 0029; 0030; 0031; 0032
(2017/04/11)
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- Naphthylacetic acid naphthalimide ester compound and application thereof
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The invention discloses a naphthylacetic acid naphthalimide ester compound of which the structure is as shown in a formula I. The naphthylacetic acid naphthalimide ester compound is used as a plant growth regulator. The compound in the formula I has excellent germination-accelerating effect, root-inducing effect and production-increasing and quality-improving effects, has a good sterilization effect, especially has a control effect on wheat sharp eyespot, phytoph-thora capsici leonian and apple ring rot at 200ppm, and can be widely applied to disease prevention and production increase in agriculture or forestry.
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Paragraph 0017; 0021-0023
(2017/07/20)
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- USE OF ORGANIC OXYIMIDES AS FLAME RETARDANT FOR PLASTIC MATERIALS AND ALSO FLAME-RETARDANT PLASTIC MATERIAL COMPOSITION AND MOULDED PARTS PRODUCED THEREFROM
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The present invention relates to the use of organic oxy imides as flame retardants for plastics. According to the present invention, a flame-retardant plastics composition is likewise specified, including an oxy imide as flame retardant. Additionally specified are mouldings produced from an inventive flame-retardant polymer composition.
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Paragraph 0173-0175
(2016/05/02)
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- Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors
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New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1- sulfonamide inhibited FGFR1 with IC50 of 2 μM. In our preliminary studies, N-phenylnaphthos-tyril- 1-sulfonamides demonstrated selectivity of FGFR1 inhibition and antiproliferative activity on cancer cell line. N-phenylnaphthostyril-1-sulfonamides have a good potential for further development as anticancer agents.
- Gryshchenko, Andrii Anatoliyovych,Levchenko, Kostiantyn Vasyliovych,Bdzhola, Volodymyr Grygorovich,Ruban, Tatiana Panasivna,Lukash, Lyubov Leonidovna,Yarmoluk, Sergiy Mikolayovych
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p. 126 - 132
(2015/03/03)
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- Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation
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Retinoic acid receptor-related orphan receptor γ (RORγ), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORγ ligand-binding domain. Among the tested compounds, s4 demonstrated RORγ antagonistic activities with micromolar IC50 values in both an AlphaScreen assay (20.27 μM) and a cell-based reporter gene assay (11.84 μM). Optimization of the s4 compound led to the identification of compounds 7j, 8c, 8k, and 8p, all of which displayed significantly enhanced RORγ inhibition with IC 50 values of 40-140 nM. These results represent a promising starting point for developing potent small molecule RORγ inhibitors.
- Zhang, Yan,Xue, Xiaoqian,Jin, Xiangyu,Song, Yu,Li, Jing,Luo, Xiaoyu,Song, Ming,Yan, Weiqun,Song, Hongrui,Xu, Yong
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p. 431 - 441
(2014/04/17)
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- Synthesis and biological evaluation of a benz[cd]indol-2(1H)-one derivatives
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Virtual screening of a library of 6.4 million compounds versus the structure of Xenopus Laevis' Aurora B kinase identified 1-(n-propyl)-6-[2-(carboxyl)tetrahydropyrrol-1-yl]sulfonyl-benzo[cd]indol-2(1H)-one 1 as a possible lead compound. Then, a novel series of benz[cd]indol-2(1H)-one derivatives were synthesized and evaluated as Aurora B kinase inhibitors. The structures of the synthetic compounds were confirmed by 1H NMR, IR, mass spectrometry and elemental analysis. These compounds were evaluated by in vitro enzyme assay using spectrophotometry. Among them, compound 7e displayed potent antitumor activity against Aurora B kinase.
- Nie, Jing,Dong, Dan-Dan,Zhang, Yan,Wang, Tai-Yi,Liu, Wei,Yi, Shou-Zhi
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p. 7329 - 7336
(2015/04/22)
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- Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents
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A series of benzo[c,d]indol-2(1H)one-PBD conjugates (11a-l) have been designed and synthesized as potential anticancer agents. These compounds were prepared by linking the C8-position of DC-81 with a benzo[c,d]indol-2(1H)one moiety through different alkane spacers in good yields and confirmed by 1H NMR, mass and HRMS data. The DNA binding ability of these conjugates was evaluated by thermal denaturation studies and interestingly, compound 11l showed enhanced DNA binding ability. These compounds were also evaluated for their anticancer activity in selected human cancer cell lines of lung, skin, colon and prostate by using MTT assay method. These new conjugates showed promising anticancer activity with IC50 values ranging from 1.05 to 36.49 μM. Moreover, cell cycle arrest in SubG1 phase was observed upon treatment of A549 cells with 1 and 2 μM (IC50) concentrations of compound 11l and it induced apoptosis. This is confirmed by Annexin V-FITC, Hoechst staining, caspase-3 activity as well as DNA fragmentation analysis.
- Kamal, Ahmed,Ramakrishna,Lakshma Nayak,Raju,Subba Rao,Viswanath,Vishnuvardhan,Ramakrishna, Sistla,Srinivas
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experimental part
p. 789 - 800
(2012/03/27)
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- Studies on the Lossen-type rearrangement of N-(3-phenylpropionyloxy) phthalimide and N-tosyloxy derivatives with several nucleophiles
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The reaction of N-(3-phenylpropionyloxy)phthalimide (1a) and N-tosyloxy (5a,b) derivatives with nucleophiles was examined and found to give the products via Lossen-type rearrangement. In order to obtain the scope of this reaction mechanism, further studies the reaction of several N-sulfonyloxyimide derivatives with various nucleophiles under similar conditions were carried out and found to afford the corresponding same types of products in high yields.
- Chanmiya Sheikh,Takagi, Shunsuke,Ogasawara, Asako,Ohira, Masayuki,Miyatake, Ryuta,Abe, Hitoshi,Yoshimura, Toshiaki,Morita, Hiroyuki
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supporting information; experimental part
p. 2132 - 2140
(2010/04/26)
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- N-Aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: Synthesis, evaluation, and substituents' effect
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Novel N-Aroyloxylthioxo-naphthalimides as highly efficient 'time-resolved' DNA photocleavers of aroyloxyl radicals type were designed and synthesized. The substituents at the aroyloxyl moiety have an important and unusual influence on the DNA photocleavage, and DNA photodamages of the compounds were unusually not depended on the electronic effects of substituents on the corresponding oxygen-centered radicals. With AM1 semi-empirical quantum calculation, it was found that their photocleaving activities were correlated with the densities of electron clouds on the N-O bonds in the triplet state. N-(m-Dichloro-benzoyloxy) -thioxo-naphthalimide could photodamage DNA effectively at less than the concentration of 2μM.
- Xu, Yufang,Huang, Xiayu,Qian, Xuhong,Yao, Wei
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p. 2335 - 2341
(2007/10/03)
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- Mild and convenient one pot synthesis of N-hydroxyimides from N-unsubstituted imides
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A new, one pot synthesis of various N-hydroxyimides from N-unsubstituted imides is described. Imides are first transformed into their N-Boc derivatives, which are next reacted with aqueous hydroxylamine, providing crystalline hydroxylammonium salts of the corresponding N-hydroxyimides. Filtration and acidic workup affords pure N-hydroxyimides.
- Einhorn,Einhorn,Marcadal-Abbadi
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p. 741 - 748
(2007/10/03)
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- Process for the preparation of cyclic N-hydroxydicarboximides
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The invention discloses a process for the preparation of cyclic N-hydroxydicarboximides, involving reacting a dicarboxylic acid or anhydride thereof with a salt of hydroxylamine in solution without the further addition of a base.
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- Reactions of amines with N-hydroxy-, N-(2,3-epoxypropoxy)succinimide and naphthalimide
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N-Hydroxynaphthalimide (1) and N-hydroxysuccinimide (2) have been prepared. 1 is stable towards alkali, while 2 undergoes hydrolysis at room temperature in the presence of alkali. 1 reacts with amines to form only the salts while 2 reacts with an equivalent amount of primary aliphatic amine to form monoamide of succinamic acid and with an excess of a primary aliphatic amine it forms diamide of succinic acid.It reacts with an aromatic primary amine, irrespective of its concentration, to form only the mono amide of succinamic acid.N-(2,3-Epoxypropoxy)naphthalimide (9) and -succinimide (13) have been prepared from 1 and 2, respectively. 9 on reaction with amines form N-(3-amino-2-hydroxypropoxy)naphthalimides (10). 13 reacts with secondary amines to form 1,3-bisamino-2-propanol, while with aniline it forms N-(3-phenylamino-2-hydroxypropoxy)succinimide.
- Ranadive, V. B.,Samant, S. D.
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p. 102 - 106
(2007/10/02)
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