- 3,4-Dihydrothienopyrimidines. II. Synthesis and Sodium Borohydride Reduction of 2-Substituted 4-Chloro- and 4-Unsubstituted-thienopyrimidines
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The synthesis and sodium borohydride reduction of 4-chloro- (1) and 4-unsubstituted- (3) 5,6,7,8-tetrahydrobenzothienopyrimidines, substituted with various groups, such as chloro, hydrogen, methyl, phenyl, amino, ethoxy, methylthio, methylsulfin
- Yamaguchi, Hitoshi,Ishikawa, Fumiyoshi
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p. 326 - 332
(2007/10/02)
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- Synthesis and Reactions of 2-Chloro-3,4-dihydrothienopyrimidines and -quinazolines
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Reaction of 2,4-dichlorothienopyrimidines and -quinazolines 1 with sodium borohydride gave the corresponding 2-chloro-3,4-dihydro derivatives 2.Some nucleophilic substitutions of 2b afforded 2-substituted derivatives 3b-7b and reaction of 2g,h with ethyl bromoacetate yielded selectively the corresponding 3-substituted compounds 8g,h which were derived to imidazoquinazolin-2-ones 9g,h.
- Yamaguchi, Hitoshi,Ishikawa, Fumiyoshi
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