- IRAK DEGRADERS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 2654; 2655
(2019/07/10)
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- ANTI-HIV COMPOUNDS
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This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.
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Paragraph 0306
(2016/07/05)
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- An unprecedented deoxygenation protocol of benzylic alcohols using bis(1-benzotriazolyl)methanethione
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A facile and regioselective two-step protocol for the deoxygenation of benzylic alcohols using bis(benzotriazole)methanethione has been devised. Benzotriazole derivatives, namely, benzyloxythioacylbenzotriazoles (ROCSBt), on reaction with silanes or Bu3SnH under microwave irradiation or conventional heating undergo a free radical β-scission of C-O bond instead of N-N bond (benzotriazole ring cleavage) to afford a deoxy product. The methodology has various applications because it selectively deoxygenates benzylic alcohols with the aid of a relatively nontoxic (TMS)3SiH reagent as an acceptable alternate to Bu3SnH.
- Kumar, Dhananjay,Singh, Anoop S.,Tiwari, Vinod K.
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p. 31584 - 31593
(2015/04/22)
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- Ti-catalyzed homolytic opening of ozonides: A sustainable C-C bond-forming reaction
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The unprecedented homolytic opening of ozonides promoted and catalyzed by titanocene(III) is reported. This novel reaction proceeds at room temperature under neutral, mild conditions compatible with many functional groups and provides carbon radicals suitable to form C-C bonds via both homocoupling and cross-coupling processes. The procedure has been advantageously exploited for the straightforward synthesis of the natural product brittonin A.
- Rosales, Antonio,Munoz-Bascon, Juan,Lopez-Sanchez, Cristobal,Alvarez-Corral, Miriam,Munoz-Dorado, Manuel,Rodriguez-Garcia, Ignacio,Oltra, J. Enrique
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p. 4171 - 4176
(2012/06/18)
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- Benzoylpyridine derivative or its salt, fungicide containing it as an active ingredient, its production process and intermediate for producing it
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The present invention relates to a fungicide containing a novel benzoylpyridine derivaitive or its salt. The present invention provides a fungicide containing a benzoylpyridine derivative represented by formula (I) or its salt: wherein X is a halogen atom, a nitro group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cyclo(alkoxy group, a hydroxyl group, a substitutable hydrocarbon group, a substitutable alkylthio group, a cyano group, a carboxyl group which may he esterified or amidated, or at substitutable amino group; n is 1, 2, 3 or 4; R1 is a substitutable alkyl group, R2 is a substitutable alkyl group, it substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group; and m is 1, 2, 3 or 4, provided that when m is at least 2, R2 may contain an oxygen atom to form a condensed ring.
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Page/Page column 10
(2008/06/13)
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- The Huang-Minlon modification of Wolff-Kishner reduction in rapid and simple way using microwave technology
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A high yielding, simple and fast method for the reduction of various aldehydes and ketones to the respective hydrocarbons following Huang-Minlon modification tender microwave irradiation is described.
- Chattopadhyay, Sarmishtha,Banerjee, Sajal Kumar,Mitra, Alok Kumar
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p. 906 - 907
(2007/10/03)
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- Isomeric Monomethyl Ether Derivatives of (RS)-9,10-Dihydroxyaporphine ("Isoapomorphine") as Possible Products of Metabolism by Catechol-O-methyltransferase
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The isomeric monomethyl ether derivatives of (RS)-9,10-dihydroxyaporphine ("isoapomorphine") were synthesized unequivocally as possible metabolites in catechol-O-methyltransferase (COMT) mediated O-methylation reactions.In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine (10,11-dihydroxyaporphine) is converted in high yield into its 10-methyl ether, apocodeine.The in vivo dopaminergic inactivity of isoapomorphine (as compared with that of apomorphine) seems to be due to factors other than metabolic inactivation by COMT.
- Cannon, Joseph G.,Qijie, Pang
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p. 1079 - 1082
(2007/10/02)
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