cas 783325-25-7, (R)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE | Articles data ｜lookchem

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783325-25-7

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Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists
Piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been demonstrated to be potent and selective adenosine A 2a receptor antagonists with oral activity in rodent models of Parkinson's disease. We have replaced
Vu, Chi B.,Pan, Deborah,Peng, Bo,Kumaravel, Gnanasambandam,Smits, Glenn,Jin, Xiaowei,Phadke, Deepali,Engber, Thomas,Huang, Carol,Reilly, Jennifer,Tam, Stacy,Grant, Donna,Hetu, Gregg,Petter, Russell C.
p. 2009 - 2018
(2007/10/03)

TRIAZOLOTRIAZINES AND PYRAZOLOTRIAZINES AND METHODS OF MAKING AND USING THE SAME
The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson’s disease. In one embodiment, the invention features a compound of formula I: (I)
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Page 32; 33

(2010/02/09)

TRIAZOLO[1,5-A]PYRIMIDINES and PYRAZOLO[1,5-A]PYRIMIDINES AND METHODS OF MAKING AND USING THE SAME
The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I) .
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Page 24-25

(2010/02/09)

TRIAZOLO[1,5-C]PYRIMIDINES and PYRAZOLO[1,5-C]PYRIMIDINES AND METHODS OF MAKING AND USING THE SAME
The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I) .
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Page 24-25

(2010/02/09)

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Chemical Properties

Boiling Point: 282℃
Flash Point:124℃
Density: 1.004
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
PSA: 41.57000
LogP: 1.93410

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