- Water promoted iodotrimethyl silane reactions: Reductive cleavage of isoxazolidines and 2,1-benzisoxazoles to γ-amino alcohols and o-aminobenzophenones
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Water promoted iodotrimethyl silane [ITMS] reductively cleaved isoxazolidines and 2,1-benzisoxazoles to γ-amino alcohols and o-aminobenzophenones respectively at shorter times and in higher yields at room temperature.
- Boruah, Monalisa,Konwar, Dilip
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p. 601 - 603
(2007/10/03)
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- Inhibitors of protein tyrosine kinases
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Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.
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- A convenient method for the production of ortho-amino and N-alkylaminobenzophenones
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ortho-Amino and N-alkylaminobenzophenones 3 have been prepared in good yields by the reductive cleavage of 2,1-benzisoxazole and its salts with Zn-AlCl3*6H2O/THF system.
- Dutta, Dilip Kumar,Konwar, Dilip
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p. 690 - 691
(2007/10/02)
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- A CONVENIENT SYNTHESIS OF 2-AMINOBENZOPHENONES USING IODOTRIMETHYLSILANE.
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Iodotrimethylsilane reduces 3-aryl-2,1-benzisoxazole to o-amino-benzophenones.
- Konwar, D.,Boruah, R. C.,Sandhu, J. S.,Baruah, J. N.
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p. 1053 - 1058
(2007/10/02)
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- Immunoassay for N-desmethyldiazepam
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Highly specific antibodies to N-desmethyldiazepam are obtained by using as an immunogen 4'-hydrazinocarbonylmethoxy-N-desmethyldiazepam coupled to an immunogenic carrier material such as bovine serum albumin. These antibodies can be employed in immunoassa
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- Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development
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The syntheses of some 1,4-benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs.
- Earley,Fryer,Ning
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p. 845 - 850
(2007/10/04)
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- Benzodiazepine radioimmunoassay using I125-label
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An improved radioimmunoassay for benzodiazepines such as diazepam, chlordiazepoxide, oxazepam, demoxepam and metabolites thereof is disclosed. Such immunoassay employs novel 125 I-labelled 4'-hydroxy derivatives of these compounds as tracer.
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