Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2
GalR1 and GalR2 represent unique pharmacological targets for treatment of seizures and epilepsy. A novel series of 2,4,6-triaminopyrimidine derivatives were synthesized and found to have sub-micromolar affinity for GalR2. Optimization of a series of 2,4,6
Sagi, Vasudeva Naidu,Liu, Tianyu,Lu, Xiaoying,Bartfai, Tamas,Roberts, Edward
scheme or table
p. 7210 - 7215
(2012/01/15)
HETEROARYL COMPOUNDS
This invention relates to compounds of formula (I) their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
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Page/Page column 99-100
(2010/11/30)
Simplified analogues of acyclonucleosides. Synthesis of 6-[N-alkyl-N-(4- hydroxybutyl)amino]pyrimidine derivatives
The synthesis of some 6-alkylaminopyrimidine derivatives bearing a 4- hydroxybutyl chain as sugar mimic is described. These new compounds can be regarded as simplified, ring-opened analogues of purine acyclonucleosides.
Botta,Saladino,Anzini,Corelli
p. 1769 - 1777
(2007/10/02)
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