- (S)-3-(2-(4-(BENZYL)-3-OXOPIPERAZIN-1-YL)ACETAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CASPASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES
-
The present invention relates to (S)-3-(2-(4-(benzyl)-3-oxopiperazin-l- yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating e.g. cardiovascular, kidney, liver, lung, skin, joints, CNS, inflammatory and autoimmune diseases.
- -
-
-
- SYNTHESIS OF 1-ALKYL(ARALKYL)-4-ACYL-2-PIPERAZINONES
-
1-Alkyl(aralkyl)-4-acyl-2-piperazinones are formed in high yelds during selective acylation of N-monosubstituted ethylendiamines by benzoyl and cyclohexylcarbonyl chlorides in the presence of pyridine hydrochloride and treatment of the reaction products w
- Tsizin, Yu.S.,Sergovskaya, N.L.,Chernyak, S.A.
-
p. 421 - 424
(2007/10/02)
-
- Piperazinone and piperazine polypeptides
-
Piperazinone polypeptides which are useful as analgesics and psychotherapeutic agents as well as processes to produce them are described.
- -
-
-