Isothiourea-Catalyzed Atropselective Acylation of Biaryl Phenols via Sequential Desymmetrization/Kinetic Resolution
Axially chiral phenols are attractive targets in organic synthesis. This motif is central to many natural products and widely used as precursors to, or directly, as chiral ligands and catalysts. Despite their utility few simple catalytic methods are avail
Brueckner, Alexander C.,Campbell, Andrew D.,Cheong, Paul Ha-Yeon,Feoktistova, Taisiia,Grove, Markas A.,Munday, Elizabeth S.,Slawin, Alexandra M. Z.,Smith, Andrew D.,Walden, Daniel M.,Young, Claire M.
supporting information
p. 7897 - 7905
(2020/03/23)
An extremely active catalyst for the Negishi cross-coupling reaction
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (triand tetra-ortho- substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.
Milne, Jacqueline E.,Buchwald, Stephen L.
p. 13028 - 13032
(2007/10/03)
More Articles about upstream products of 787618-25-1