- Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability
-
A set of novel diarylisoxazoles has been projected using mofezolac (1) as a lead compound to investigate structure-inhibitory activity relationships of new compounds and the cyclooxygenases (COXs) catalytic activity. Mofezolac was chosen because is the mo
- Pati, Maria Laura,Vitale, Paola,Ferorelli, Savina,Iaselli, Mariaclara,Miciaccia, Morena,Boccarelli, Angelina,Di Mauro, Giuseppe Davide,Fortuna, Cosimo G.,Souza Domingos, Thaisa Francielle,Rodrigues Pereira da Silva, Luiz Cláudio,de Pádula, Marcelo,Cabral, Lucio Mendes,Sathler, Plínio Cunha,Vacca, Angelo,Scilimati, Antonio,Perrone, Maria Grazia
-
-
- Process for producing isoxazole derivatives
-
The present invention provides a process for producing isoxazole derivatives represented by the formula STR1 wherein R1 and R2 are the same or different and are each a hydrogen atom or lower alkoxyl, and R3 is cyano or alk
- -
-
-
- α, β-unsaturated ketones and ketoxime derivatives
-
The present invention provides an α, β-unsaturated ketone and ketoxime derivative represented by the formula STR1 wherein Y is oxygen atom or hydroxyimino group, Z is cyano or alkoxycarbonyl group, R1 and R2 are the same or different
- -
-
-
- 3,4-Diarylisoxazol-5-acetic acids and process for making same
-
3,4-Diarylisoxazol-5-acetic acids of the formula STR1 in which Ar1 and Ar2 are the same or different and are selected from phenyl and naphthyl, R1, R2, R3, and R4 are the same or different and are selected from hydrogen, halogen, trifluoromethyl, lower alkyl, and lower alkoxy, and R5 is selected from hydrogen, lower alkyl, and lower alkoxy. The compounds have anti-inflammatory, analgesic, and anti-pyretic activities and a low order of toxicity, and methods for their preparation and use are also disclosed.
- -
-
-