- Method for synthesizing m-iodonitrobenzene compound
-
Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.
- -
-
Paragraph 0090-0091
(2018/03/24)
-
- 5, 7-DIHYDRO- 6H-PYRIMIDO [ 5, 4-D] [ 1 ] BENZAZEPIN-6-THIONES AS PLK INHIBITORS
-
This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
- -
-
Page/Page column 58-59
(2010/06/20)
-
- Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists
-
A high throughput screening approach to the identification of selective cholecystokinin-2 receptor (CCK-2R) ligands resulted in the discovery of a novel series of antagonists, represented by 1-[2-[(2,1,3-benzothiadiazol-4- ylsulfonyl)amino]-5-chlorobenzoy
- Allison, Brett D.,Phuong, Victor K.,McAtee, Laura C.,Rosen, Mark,Morton, Magda,Prendergas, Clodagh,Barrett, Terry,Lagaud, Guy,Freedman, Jamie,Li, Na,Wu, Xiaodong,Venkatesan, Hariharan,Pippel, Marna,Woods, Craig,Rizzolio, Michèle C.,Hack, Michael,Hoey, Kenway,Deng, Xiaohu,King, Christopher,Shankley, Nigel P.,Rabinowitz, Michael H.
-
p. 6371 - 6390
(2008/04/18)
-
- Quinoxaline compounds
-
Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
- -
-
Page/Page column 14
(2008/06/13)
-
- Benzo[1,2,5]thiadiazole compounds
-
Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
- -
-
-