1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and ad
Beadle, Christopher D.,Boot, John,Camp, Nicholas P.,Dezutter, Nancy,Findlay, Jeremy,Hayhurst, Lorna,Masters, John J.,Penariol, Roberta,Walter, Magnus W.
p. 4432 - 4437
(2007/10/03)
TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS
Provided are methods and medicaments for treating a learning disability or a Motor Skills Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.
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Page/Page column 202
(2010/02/11)
TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH NOREPINEPHRINE REUPTAKE INHIBITORS
Provided are methods and medicaments for treating a Pervasive Developmental Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.
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Page/Page column 205
(2010/02/11)
TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION
Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.
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Page/Page column 205
(2010/02/12)
QUINOLONE DERIVATIVES
This invention relates to compounds of formula (I) where -X-, n, R1, R3 and Ar- have the values defined herein, their preparation and use as norepinephrine reuptake inhibitors useful for the treatment of nervous system disorders
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Page 19
(2010/02/09)
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