- NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
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The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.
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Page/Page column 114-115
(2013/04/24)
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- USE OF THIAZOLIUM-2-CARBOXYLATES TO INDUCE BENZOIN CONDENSATIONS
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The preparation of 3-ethyl-4,5-dimethylthiazolium-2-carboxylate and its use to promote the benzoin condensation and the formoin reaction is described.
- Castells, J.,Calahorra, F. Lopez,Domingo, L.
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p. 5457 - 5458
(2007/10/02)
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- An Infrared Study of Rotational Isomerism in Thiazole-2-carboxylates
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A series of alkyl thiazole-2-carboxylates containing a range of substituents at the 4- and 5-positions has been prepared.Solutions of these esters (mostly new compounds) show well resolved doublets in the i.r.C=O region which arise from rotational isomers.The higher wavenumber components are assigned to the more polar carbonyl O,S-anti-s-trans-rotamers and the lower wavenumber components to the carbonyl O,S-syn-s-trans-forms.Small, but systematic, differences between the methyl esters are noted.
- Kaye, Perry T.,Meakins, G. Denis,Willbe, Charles,Williams, Peter R.
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p. 2335 - 2339
(2007/10/02)
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