- Synthesis of a dexamethasone-21-maleimido-linked derivative as a potential molecule for specific gene delivery
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The synthesis of the dexamethasone-21-maleimido-linked derivative 5 is described for the first time. The two principal steps of this synthesis are (1) the formation of a stable urethane 3 and (2) the introduction of a reactive maleimido group via a linker
- Bernasconi, A.,Rebuffat, A.,Bigler, P.,Frey,Frey
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- TARGETED STEROID CONJUGATES
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A compound of the formula (I): G1-L-G2, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein G1 is a folate radical, an antifolate radical, or a folate analog radical; L is a linker; and G2 is a radical of a steroid; compositions comprising such compounds; and the use of such compounds and compositions to treat, for example, inflammation associated with a disease or disorder.
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Paragraph 00309; 00311; 00320; 00321
(2021/07/17)
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- CONJUGATES OF CARTILAGE-HOMING PEPTIDES
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Compositions such as pharmaceutical compositions and uses for peptide-drug conjugates are disclosed. Such compositions can deliver a drug, a peptide, or a conjugate thereof to a target region, tissue, structure or cell in cartilage.
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Paragraph 0363; 0365
(2019/11/12)
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- GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING GLUCOCORTICOID RECEPTOR ACTIVITY
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Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein
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Paragraph 00966
(2013/06/05)
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- Conjugates of DNA interacting groups with steroid hormones for use as nucleic acid transfection agents
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The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids into the nucleus of
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Page column 18
(2010/02/07)
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- Cell-Specific Ligands for Selective Drug Delivery to Tissues and Organs
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Various numbers of D-mannose residues have been attached via spacer arms to lysine, dilysine, and oligolysine backbones.These D-mannosyl peptide analogues were found to be potent competitive inhibitors of the uptake of 125I-labelled D-mannose-bovine serum
- Ponpipom, Mitree M.,Bugianesi, Robert L.,Robbins, James C.,Doebber, T. W.,Shen, T. Y.
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p. 1388 - 1395
(2007/10/02)
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