The synthesis and structure-activity relationship studies of novel indole derivatives as peroxisome proliferator-activated receptor (PPAR) agonists are reported. Indole, a druglike scaffold, was studied as a core skeleton for the acidic head part of PPAR
THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS
The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.
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Page 52-53
(2010/11/30)
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human PPaR γ, δ and α agonists
A series of amphipathic 3-phenylbenzisoxazoles were found to be potent agonists of human PPARα, γ and δ. The optimization of acid proximal structure for in vitro and in vivo potency is described. Results of po dosed efficacy studies in the db/db mouse mod
Adams, Alan D.,Yuen, Winston,Hu, Zao,Santini, Conrad,Jones, A. Brian,MacNaul, Karen L.,Berger, Joel P.,Doebber, Thomas W.,Moller, David E.
p. 931 - 935
(2007/10/03)
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