- Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents
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p53-Murine double minute 2 (MDM2) interaction and histone deacetylases (HDACs) are important targets in antitumor drug development. Inspired by the synergistic effects between MDM2 and HDACs, the first MDM2/HDACs dual inhibitors were identified, which sho
- He, Shipeng,Dong, Guoqiang,Wu, Shanchao,Fang, Kun,Miao, Zhenyuan,Wang, Wei,Sheng, Chunquan
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p. 7245 - 7260
(2018/08/03)
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- A practical synthesis of a cis -4,5-Bis(4-chlorophenyl)imidazoline Intermediate for Nutlin analogues
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A practical synthesis of cis-4,5-bis(4-chlorophenyl)imidazoline, a key intermediate for Nutlin analogues, is reported. The title compound was prepared in 81-88% yield by boric acid catalyzed direct condensation of meso-bis(4-chlorophenyl)ethane-1,2-diamine with a benzoic acid. The process was successfully scaled up in a pilot plant, resulting in >15 kg of the product.
- Shu, Lianhe,Wang, Ping,Liu, Wen,Gu, Chen
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p. 1866 - 1869
(2013/01/15)
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