- SYNTHESIS OF 2'- OR 3'-O-(4-METHOXYBENZYL)NUCLEOSIDES AND ITS APPLICATION IN THE 3'-TERMINAL NONANUCLEOTIDE SEQUENCE OF ROUS SARCOMA VIRUS 35S RNA SYNTHESIS
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2'- or 3'-O-(4-Methoxybenzyl)nucleoside derivatives were synthesized by treatment of uridine, N4-benzoylcytidine, N6-benzoyladenosine, and N2-benzoylguanosine with 4-methoxyphenyldiazomethane.The separation of 2'- or 3'- i
- Kamaike, Kazuo,Tsuchiya, Hiromichi,Imai, Kazuaki,Takaku, Hiroshi
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p. 4701 - 4712
(2007/10/02)
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- Synthesis of Ribooligonucleotides Using the 4-Methoxybenzyl Group as a New Protecting Group for the 2'-Hydroxyl Group
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The 4-methoxybenzyl group was introduced to protect the 2'-hydroxyl group of uridine, cytidine, and N2-benzoylguanosine by treatment of 2',3'-O-(dibutylstannylene)uridine or NaH-treated nucleosides with 4-methoxybenzyl bromide.The 2'-O-(4-methoxybenzyl)nucleosides can be used as useful starting materials for the synthesis of 3',5'-linked ribooligonucleotides.The 4-methoxybenzyl group was removed rapidly from the ribooligonucleotides by treatment with triphenylmethyl fluoroborate, and the completely deblocked ribooligonucleotides were characterized by enzymatic hydrolysis.
- Takaku, Hiroshi,Kamaike, Kazuo,Tsuchiya, Hiromichi
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