Synthesis of some heterocycle containing urea derivatives and their anti-viral activity
Some new isoindol heterocyclic ureas (6a-6i) have been synthesized using N-aminophthalimide (2) and ethyl N-monosubstituted/ethyl N,N-disubstituted carbamate (5a-5i). All the newly synthesized final compounds have been evaluated for their anti-viral activities against a variety of viruses. The compound (6f) with the methoxy substituent showed reasonably better activity as compared to the standard drugs against all the viruses (cf. Tables 1, 2 and 3). Further, all the products (6a-6i) were found to be active against Vesicular stomatitis virus, Coxsackie virus B4 and Respiratory syncytical virus (cf. Table 2) and the compounds (6h) and (6i) displayed better antiviral activity in comparison to Brivudin and (S)-DHPA (cf. Table 3).
Verma, Majusha,Singh, Krishna N.,Clercq, Erik D.
p. 11 - 22
(2007/10/03)
The Partitioning of the Tetrahedral Intermediate from the Basic Methanolysis of Ethyl N-Aryl-N-methylcarbamates
The ratio of amine to methyl carbamate from the title reaction provides information on the relative nucleofugalities of some amines and the ethoxide anion, which is consistent with previously postulated mechanism for basic amide methanolysis.
Broxton, Trevor J.,Deady, Lesle W.,Lim, Richard H. K.
p. 1993 - 1996
(2007/10/02)
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