THE SYNTHESIS OF SUBSTITUTED 2H-1,2-BENZOTHIAZINES 1,1-DIOXIDES
The base-catalyzed rearrangement of the esters of 2H-1,2-benzothiazolin-3-one-2-acetate 1,1-dioxide (IIa-IIc) afforded substituted 2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides IIIa-IIIc.After N-alkylation and aminolysis the antiinflammatory drugs piroxicam and isoxicam were obtained.
Svoboda, Jiri,Palecek, Jaroslav,Dedek, Vaclav
p. 1133 - 1139
(2007/10/02)
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