- 'HALEX' FLUORINATION OF CHLORINATED BENZALDEHYDES AND BENZOYL CHLORIDES
-
Spray-dried potassium fluoride, suspended in sulpholane at 220 degC, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields ca. 65percent).Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluorobenzaldehyde, and 2-chloro-6-fluoro-benzaldehyde, respectively) were also produced.Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98percent, conversion 68percent), but 2- and 4-chlorobenzaldehyde gave very poor yields (ca. 5percent) of the 2- and 4-fluoro-derivatives. 2-Fluoro-, 4-fluoro- and 3-chloro-4-fluorobenzoyl fluoride were obtained (yields 60-65percent) by heating the corresponding chlorobenzoyl chlorides with potassium fluoride in sulpholane.
- Banks, R. Eric,Mothersdale, Kevin N.,Tipping, Anthony E.,Tsiliopoulos, Efthimios,Cozens, Barry J.,et al.
-
p. 529 - 537
(2007/10/02)
-
- POLYMER-SUPPORTED AMINOPYRIDINIUM SALTS AS VERSATILE CATALYSTS FOR THE SYNTHESIS OF ARYL FLUORIDES
-
Immobilized N-alkylaminopyridinium salts on divinylbenzene crosslinked polystyrene gel was reusable at least 8 times on the reaction of 4-chloronitrobenzene with anhydrous potassium fluoride in tetrahydrothiophene 1,1-dioxide to give 4-fluoronitrobenzene in high yield.The immobilized catalyst was also successfully used for a synthesis of several aryl fluorides in good yields.
- Yoshida, Yasuo,Kimura, Yoshizaku,Tomoi, Masao
-
p. 7199 - 7202
(2007/10/02)
-