- Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas
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A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.
- Martinez, Jean,Oiry, Joel,Imbach, Jean Louis,Winternitz, Francois
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p. 178 - 182
(2007/10/02)
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