- Development of novel NLRP3-XOD dual inhibitors for the treatment of gout
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Gout is a crystalline-related arthropathy caused by the deposition of monosodium urate (MSU). Acute gouty arthritis is the most common first symptom of gout. Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition r
- Wang, Weiwei,Pang, Jing,Ha, Eun Hee,Zhou, Mengze,Li, Zhubin,Tian, Sheng,Li, Huanqiu,Hu, Qinghua
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supporting information
(2020/01/13)
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- Convenient synthesis of novel 5-substituted 3-methylisoxazole-4- sulfonamides
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A number of novel sulfonamide derivatives of 5-substituted-3- methylisoxazole were synthesized and characterized, starting from 3,5-dimethylisoxazole. Key steps include the generation of 3,5- dimethylisoxazole-4-sulfonamides followed by their reactions wi
- Filimonov, Sergey I.,Korsakov, Mikhail K.,Kravchenko, Dmitry V.,Dorogov, Mikhail V.,Tkachenko, Sergey E.,Ivachtchenko, Alexandre V.
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p. 663 - 671
(2007/10/03)
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- Bispiperidines as antithrombotic agents
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Novel compounds which are inhibitors of the binding of fibrinogen to the Gp IIb/IIIa platelet receptors, and which can be used therepeutically as antithrombotic agents
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- Process for preparing 3,5-dimethylisoxazole-4-sulphonyl chloride
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By a novel process, 3,5-dimethylisoxazole-4-sulphonyl chloride is prepared by reacting 3,5-dimethylisoxazole initially with chlorosulphonic acid and then additionally with thionyl chloride at a temperature between 60° C. and 110° C.
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- Some Heterocyclic Sulfonyl Chlorides and Derivatives
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The syntheses of 4- and 5-chlorosulfonylfuran-2-carboxylic acid (Ia,IIa), 4-chlorosulfonylfuran-2-carboxamide (Ib), 3,5-dimethylpyrazole and isoxazole-4-sulfonyl chlorides (IIa, IVa) and 2,4-dimethylthiazole-5-sulfonyl chloride (Va) are described.The sulf
- Cremlyn, Richard J.,Swinbourne, Fred J.,Yung, Kin-Man
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p. 997 - 1006
(2007/10/02)
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