Analogues of the potent nonpolyglutamatable antifolate N(α)-(4-amino-4- deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: Synthesis and in vitro antitumor activity
Seven N(α)-(4-amino-4-deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (2, PT523) analogues were synthesized by modifications of the literature synthesis of the corresponding AMT (1) analogues and were tested as inhibitors of tumor cell growth. In growth assa
Rosowsky, Andre,Wright, Joel E.,Vaidya, Chitra M.,Forsch, Ronald A.,Bader, Henry
p. 1620 - 1634
(2007/10/03)
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin
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DeGraw,Brown,Tagawa,Kisliuk,Gaumont,Sirotnak
p. 1227 - 1230
(2007/10/02)
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