- NEW 5-AMINOLEVULINIC ACID PRODRUGS FOR USE IN PHOTODYNAMIC THERAPY AND PHOTODYNAMIC DIAGNOSIS
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There is provided a compound of Formula (I) or (II) and salts thereof wherein R1 is an imine or an alkylated imine, said imine or alkylated imine comprising a linear or branched alkyl group of length C1 to C5; R2 are each independently (a) an unsubstituted or substituted linear or branched alkyl group of chain length C1-7; (b) an aryl substituted alkyl group, wherein said aryl group is substituted, (c) an alkoxy substituted alkyl group, wherein said alkoxy group is substituted by a methoxy group or an alkoxy group substituted with an alkoxy group,; or (d) an H atom; wherein said substituents in (a) and (b) are selected from hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, nitro, oxo and fluoro groups. R3 and R4 are linear or branched alkyl groups of length C1 to C6 constituting a ketal or a cyclic ketal. The compounds claimed may be used for the manufacture of a medicament.
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Page/Page column 21; 23
(2010/04/06)
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- Facile synthesis of the indeno-tetrahydropyridine core of haouamine A
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(Chemical Equation Presented) The tricyclic indeno-tetrahydropyridine core of haouamine A, containing five of the seven rings of the natural product, was constructed by a simple, concise route that features an acid-catalyzed Friedel-Crafts ring closure.
- Smith, Nicole D.,Hayashida, Joji,Rawal, Viresh H.
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p. 4309 - 4312
(2007/10/03)
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- GABA uptake inhibitors. Syntheses and structure-activity studies on GABA analogues containing diarylbutenyl and diarylmethoxyalkyl N-substituents
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A number of analogues of GABA or β-alanine containing 4,4-diphenyl-3-butenyl (DPB), benzhydryl ethyl ether (BEE), or benzhydryl propyl ether N-substituents have been synthesized and tested as inhibitors of synaptosomal GABA uptake. Whereas the N-DPB and N
- Falch,Krogsgaard-Larsen
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- Electroorganic Chemistry. 60. Electroorganic Synthesis of Enamides and Enecarbamates and Their Utilization in Organic Synthesis.
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A variety of enecarbamates and enamides were synthesized from α-methoxy carbamates and α-methoxy amides prepared by anodic methoxylation of amine derivatives.Some new carbon-carbon bond-forming reactions and hydroxylation at the β position of amines have been accomplished by using these enecarbamates and enamides as key intermediates.Also, new synthetic routes of nicotinaldehyde and pyrrole derivatives have been exploited by utilizing anodic dimethoxylation of carbamates of piperidine and pyrrolidine, respectively.
- Shono, Tatsuya,Matsumura, Yoshihiro,Tsubata, Kenji,Sugihara, Yoshihiro,Yamane, Shin-ichiro,et. al.
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p. 6697 - 6703
(2007/10/02)
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- Syntheses of Some Aminopiperidinecarboxylic Acids Related to Nipecotic Acid
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This paper describes the syntheses of (3RS,5SR)-5-hydroxypiperidine-3-carboxylic acid (8), (3RS,5SR)-5-aminoperidine-3-carboxylic acid (9), (RS)-3-hydroxypiperidine-3-carboxylic acid (13), (RS)-α-amino-3-pyridineacetic acid (18), and α-amino-3-piperidineacetic acid (19), compound 19 probably being a mixture of diastereomeric racemates.The compounds 8 and 9 were prepared from 5-aminonicotinic acid by catalytic hydrogenation.The relative stereochemistry of 9 was established by 270 MHz 1H NMR spectroscopy.The α-hydroxy acid 13 was prepared via cyanhydrin reaction of the 3-piperidone derivative 11.The α-amino acids 18 and 19 were prepared from 3-pyridineacetic acid by nitrosation and subsequent catalytic hydrogenation.
- Jacobsen, Poul,Schaumburg, Kjeld,Larsen, Jens-Joergen,Krogsgaard-Larsen, Povl
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p. 289 - 294
(2011/02/21)
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