- Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design
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The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. The probes can detect HOCl, using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL-60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly release either amino- or carboxy-containing compounds from prodrugs, during HOCl detection and imaging, to realize a therapeutic effect.
- Wei, Peng,Liu, Lingyan,Wen, Ying,Zhao, Guilong,Xue, Fengfeng,Yuan, Wei,Li, Ruohan,Zhong, Yaping,Zhang, Mengfan,Yi, Tao
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supporting information
p. 4547 - 4551
(2019/03/11)
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- Cu-α-NiMoO4 photocatalyst for degradation of Methylene blue with pathways and antibacterial performance
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Cu doped α-NiMoO4 photocatalyst has been synthesized by microwave hydrothermal method. The existence of Cu2+ ions at lattice position of α-NiMoO4 was observed on the basis of XRD, HRTEM, SAED, and EDS analysis. The negative zeta potential values indicate the stability of samples. Solar light driven photocatalytic degradation of Methylene blue (MB) dye in water was used to evaluate the photocatalytic performance of Cu doped α-NiMoO4 photocatalyst. The results revealed that there is an optimum Cu (4 mol%) doping level leads to highly enhanced photocatalytic activity of Cu-α-NiMoO4, as compared to α-NiMoO4 host. The experiment also suggested that active species (OH[rad], O2[rad]? and h+) play a crucial role in the scavenging system. The reduced energy band gap, oxygen vacancy, high BET surface area, and efficient separation of photogenerated electron/hole are responsible for enhancement of photocatalytic performance. MB photodegradation intermediates were identified by high resolution-quadruple time of flight electrospray ionization mass spectrometry (HR-QTOF ESI/MS) in positive ion mode and degradation pathway was proposed. Antibacterial performance was analyzed against Gram-positive (methicillin resistant Staphylococcus aureus and Bacillus Subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa) via well-diffusion method. The formation of larger inhibition zone by small quantity of photocatalyst powder proved the excellent antibacterial performance. The inactivation of microorganism were found in following order: B.Subtilis ? S.aureus ? P.aeruginosa. The result of our study suggested that copper doped α-NiMoO4 photocatalyst is suitable for degradation of organic contaminates as well as effective for growth inhibition of multidrug-resistant microorganisms.
- Ray, Schindra Kumar,Dhakal, Dipesh,Kshetri, Yuwaraj K.,Lee, Soo Wohn
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- Catalytic removal of organic colorants from water using some transition metal oxide nanoparticles synthesized under sunlight
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Transition metal oxides (TMO) constitute a most amazing class of materials with a wide range of properties and applications; therefore, their synthesis using a green approach is a necessity. As such, sunlight irradiation was employed to synthesize various TMO nanostructures (ZnO, CuO, Co3O4, NiO and Cr2O3) using water as a solvent. Nanoparticles obtained with distinct morphologies, such as nanotubes (ZnO; 3O4; 45-90 nm), needle-shaped (NiO; 2-25 nm) and nanobeads (Cr2O3; ~17 nm) were confirmed by TEM analysis. The significance of the synthesis is in its quick approach with no thermal heat involvement, reusable catalyst, cost effectiveness and ability to fabricate almost uniformly distributed nanoparticles with small sizes. The potential of the synthesized nanoparticles was examined in the treatment of simulated water containing hazardous dyes: Alizarin Red S (ARS) + Methylene Blue (MB). Interestingly, in a short period of 180 min, 88.24% of the dye mixture was, for the most part, completely degraded using Cr2O3 nano-needles, followed by 87.96% (ZnO) > 86.86% (CuO) > 85.89% (NiO) > 80.35% (Co3O4), depending on the sizes of the respective TMO nanoparticles. This is also supported by the finding of small and non-toxic by-products such as but-2-enal, sulfur trioxide and benzoquinone. With high potential observed in the removal of dyes, TMO nanoparticles have a bright future with respect to their use as important adsorbents in waste water treatment. The advantage of the present work lies in the green synthesis of nanoparticles and their application in helping to make our environment green.
- Shanker, Uma,Jassal, Vidhisha,Rani, Manviri
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p. 94989 - 94999
(2016/10/21)
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- Effects of ionic surfactants and cyclodextrins on hydride-transfer reaction of l-Benzyl-l,4-dihydronicotinamide with methylene blue
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The kinetics of the hydride-transfer reaction between methylene blue (MB+) and 1 -benzyl-1,4-dihydronictinamide (BNAH) were studied in media containing cyclodextrins (β- and γ-CD) and surfactants (sodium dodecyl sulfate (SDS), dodecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide, and hexadecyltrimethylammonium bromide). Cationic surfactants decreased the apparent first-order rate constant (k obsd) above the cmc, while SDS increased kobsd just above the cmc and then decreased kobsd with increasing surfactant concentration. This behavior for cationic surfactants was typical of micellar effects due to a separation of the reactants by the micelles. BNAH associated with micelles, whereas MB+ ions were repelled from the cationic interface of the micelles. Binding of BNAH and MB to the same SDS micelle enhanced the reaction, but dilution of reagents within the micellar interface with the increase in [SDS] caused a decrease in Kobsd. In β-CD-cationic surfactant mixtures, the results were interpreted in terms of the model which takes into account the formation of CD-BNAH, CD-MB+, and CD-surfactant complexes and the association of BNAH with micelles. The decrease in Kobsd with increasing surfactant concentration observed in γ-CD-cationic surfactant mixtures can be explained by the decrease in the concentration of free γ-CD by the formation of 1:1 and 2:1 complexes of surfactant monomer with β-CD.
- Matsumoto, Takeshi,Liu, Yingjin,Sueishi, Yoshimi,Yamamoto, Shunzo
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experimental part
p. 1383 - 1390
(2009/06/19)
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