Ammonium 7H-Purin-6-yl 1-Thio-β-D-glycopyranosiduronate, a Latent, Selective Anticancer Agent
Ammonium 7H-purin-6-yl 1-thio-β-D-glucopyranosiduronate (1), a good substrate of β-glucuronidase, causes a 22percent decrease in the growth of L1210 cells while not affecting the growth of Chinese hamster lung fibroblasts from a nontumor line. 7H-Purin-6-yl 1-thio-β-D-glucopyranosiduronamide (2), a poor substrate of β-glucuronidase, has no effect on the growth of either cell type.
Parker, Angela,Fedor, Leo
p. 1505 - 1507
(2007/10/02)
Purine thioglycosides. I. S-Glycosides of 6-mercaptopurine.
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Goodman,Salce,Hitchings
p. 516 - 521
(2007/10/05)
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