- POLYHYDROXYLATED BILE ACIDS FOR TREATMENT OF BILIARY DISORDERS
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The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis or portal hypertesion. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow. New compounds 2α,3α,7α,12α-tetrahydroxy-5β-cholanoic acid and 3α,4α,7α,12α-tetrahydroxy-5β-cholanoic acid are disclosed, uses thereof and synthesis thereof.
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Page/Page column 38
(2011/04/14)
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- Potential bile acid metabolites. 16. Synthesis of stereoisomeric 3α,6,7,12α-tetrahydroxy-5β-cholanoic acids
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New synthetic routes to the four possible stereoisomeric 3α,6,7,12α-tetrahydroxy-5β-cholanoic acids (and their methyl esters), one of which (3α,6α,7β,12α) is new, and some related compounds are described.In addition, the 5α-epimer of the new acid was obtained.The final products were obtained in high purity for use as reference compounds in the analysis of bile acids in human biologic samples.The results of analysis of the prepared stereoisomers by proton and carbon 13 nuclear magnetic resonance spectroscopies are briefly discussed along with the thin-layer and gas-liquid chromatographic properties.
- Iida, Takashi,Komatsubara, Ichiro,Yoda, Seiichiro,Goto, Junichi,Nambara, Toshio,Chang, Frederic C.
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p. 530 - 539
(2007/10/02)
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- Identification of 3,6,7,12-tetrahydroxy-5β-cholan-24-oic acids in human biologic fluids
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Unusual bile acids, 3α,6α,7α,12α-, 3α,6β,7β,12α-, and 3α,6β,7β,12α-tetrahydroxy-5β-cholan-24-oic acids, were identified in all amniotic fluid (four samples) and urine (six samples) from adult patients with cholestalic liver disease by gas-liquid chromatography/mass spectrometry. For the certain identification of these bile acids in the biologic samples, the chemical syntheses of 3α,6β,7α,12α- and 3 α,6β,7β,12α-tetrahydroxy-5β-cholan-24-oic acids were conducted. (Steroids 55:512-515, 1990).
- Yoshii, Michiko,Kihira, Kenji,Shoda, Junichi,Osuga, Toshiaki,Hoshita, Takahiko
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p. 512 - 515
(2007/10/02)
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