- 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor
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This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
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Page/Page column 55
(2010/11/08)
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- Occurrence of Even Telesubstitution in the Amination of Halogeno-2,6-naphthyridines
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The conversion of 1-halogeno-2,6-naphthyridines into 1-amino-2,6-naphthyridine is shown to proceed via an even telesubstitution process N(AE)tele process>.The amination of 2-bromo-1,5-naphthyridine into 2-amino-1,5-naphthyridine is shown to proceed via an SN(AE)ipso substitution mechanism.
- Haak, Henk J. W. van den,Plas, Henk C. van der
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p. 1673 - 1677
(2007/10/02)
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- Amination of 2,6- and 2,7-Naphtyridine. An NMR Study on ?-Adducts of Heterocyclic Systems with Amide Ions
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A facile synthesis of 2,6-naphtyridine is described.Both 2,6- and 2,7-naphtyridine undergo with potassium amide under kinetically and thermodynamically controlled conditions ?-adduct formation at position 1.Chichibabin amination of 2,6-naphtyridine yields 1-amino-2,6-naphtyridine in 54percent yield.
- Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van
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p. 1349 - 1352
(2007/10/02)
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