Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes
A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.
Li, Meina,Kong, Duanyang,Zi, Guofu,Hou, Guohua
p. 680 - 687
(2017/04/26)
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