- Stilbene type compound as well as synthesis method and application thereof
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The invention discloses a stilbene type compound as well as a synthesis method and application thereof, wherein the synthesis method comprises the steps: taking an intermediate 2 and an intermediate 4 as initiators, sequentially carrying out Wittig reaction, reduction reaction, amino protection reaction, condensation reaction, deprotection reaction and amidation reaction, and then refining to obtain the stilbene type compound. The synthesis process is high in controllability, used reagents are low in price, and the method is simple and easy to industrialize. The stilbene type compound can be used as a medicine for resisting tumors and viruses and treating fungal infection and cardiovascular and cerebrovascular diseases.
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- Nitrogen doped carbon supported iron catalysts for highly selective production of 4,4′-diamino-2,2′-stilbenedisulfonic acid
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Nitrogen doped carbon supported iron catalysts were prepared from pyrolysis of a multidentate nitrogen ligand iron complex supported on chitosan at different temperature, and showed good performances in the reduction of 4,4′-dinitrostilbene-2,2′-disulfonic acid (DNS acid) to 4,4′-diamino-2,2′-stilbenedisulfonic acid (DSD acid) with hydrazine hydrate (N2H4·H2O) as reductant. Characterization results revealed that the iron is mainly present in the form of Fe2O3 and metallic iron nanoparticles. The doped N atoms functionalized as anchoring sites to stabilize iron nanoparticles, which endows the catalysts with excellent activity and superior reusability.
- Cao, Pengwei,Zhang, Hong-Yu,Yin, Guohui,Zhang, Yuecheng,Zhao, Jiquan
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- A reduction of nitro aromatic substituent amino aromatic of substituted method (by machine translation)
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The invention relates to amino aromatic substituted object synthesis technology field, in particular to a process for preparing nitro aromatic substituent amino aromatic of substituted method. The method comprises the following steps, water, catalyst is added to the 1st in the reactor, and the reactor temperature, adding reducing iron, adjusting pH, at the same time added to the 1st nitro aromatic substituent in the reactor, thermal insulation reaction, to obtain a reaction liquid; regulating the reaction liquid of pH, thermal reaction, the addition of a stabilizing agent, containing the amino aromatic of substituted 1st solution and iron oxide black crude; adjusting the pH of the 1st solution, solid-liquid separation, obtained amino aromatic substituent. The present invention provides a process for the production of the method is simple, can be continuously produced, with high operation safety and higher selectivity, the reaction time is short, a yield as high as 90% or more, the product quality is good, the content of 98% or more. (by machine translation)
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Paragraph 0043-0047; 0073-0077
(2019/06/13)
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- DSD acid preparation method
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The invention relates to the field of chemical synthesis, in particular to a DSD acid preparation method. The DSD acid preparation method includes the steps that methylbenzene is subjected to sulfonation, purification and separation to obtain OTS, wherein the byproduct is PTS; OTS is subjected to mixed acid nitration to obtain PNTS; PNTS is subjected to chlorine oxidative condensation to obtain DNS; DNS is subjected to catalyzed hydrogeneration reduction to obtain the high-quality target product, namely DSD acid which can be directly used for synthesizing a fluorescent whitening agent. The synthesis method greatly reduces dangerousness of the process, greatly reduces generation of harmful byproducts and waste, particularly, does not generate a lot of carcinogenic intermediate, namely ortho-nitrotoluene, completely solves the nitration safety problem of the old technology, and has the advantages of being simple in step, high in yield and the like.
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- Preparation method of 4,4'-diamino diphenylethene-disulfonic acid
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The invention discloses a preparation method of 4,4'-diamino diphenylethene-disulfonic acid. 4,4'-binitro diphenylethene-disulfonic acid or 4,4'-binitro diphenylethene-disulfonate serves as a raw material, the raw material and a supported catalyst are co-dispersed in a solvent, and 4,4'-diamino diphenylethene-disulfonic acid is prepared through a hydrogenation reaction. Based on the total mass of the supported catalyst, active ingredients in the supported catalyst comprise, by mass, 0.1-10% of platinum, 0-5% of ruthenium and 0-5% of iridium, wherein the mass fraction of ruthenium and the mass fraction of iridium cannot be 0 at the same time. According to the preparation method of 4,4'-diamino diphenylethene-disulfonic acid, the high-activity and high-selectivity supported catalyst is adopted, and the produced product reaches the China chemical industry standard HG/T 2279-2011.
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Paragraph 0056; 0057; 0058; 0060
(2017/04/29)
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- Facile, mild and convenient preparation and characterization of some novel schiff base ligands from synthetic diamines and salicylaldehyde
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Some novel Schiff base ligands have been prepared through condensation of salicylaldehyde with synthetic various primary diamines under mild reaction conditions. The used aromatic diamines were synthesized in good yields starting from low-cost commercially available materials. In these reactions, the Schiff base products have been afforded with excellent yields and appropriate reaction times. The structure of these ligands has been characterized by IR, 1H NMR and 13C NMR techniques.
- Naeimi, Hossein,Heidarnezhad, Arash
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p. 117 - 122
(2015/01/30)
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- Supported nano-sized gold catalysts for selective reduction of 4,4′-dinitrostilbene-2,2′-disulfonic acid using different reductants
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Gold nanoparticles supported on three metal oxides, TiO2, Al2O3 and Fe2O3, were prepared by a modified precipitation-deposition method using urea as an additive. These catalysts were tested in chemoselective reduction of 4,4′-dinitrostilbene- 2,2′-disulfonic acid to 4,4′-diaminostilbene-2,2′-disulfonic acid. Three reagents, hydrogen, carbon monoxide, and sodium formate, were employed as reductants. It was found that >94% of the nitrostilbene was transformed into the aminostilbene without the reduction of olefinic group. In addition, these catalysts exhibited stable performance after regeneration by calcination at 400 °C for 5 h. This clean approach provides a promising application for synthesis of amino substituted stilbene sulfonic acid on an industrial scale.
- Chen, Ying,Peng, Wenchao,Wang, Shaobin,Zhang, Fengbao,Zhang, Guoliang,Fan, Xiaobin
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experimental part
p. 215 - 220
(2012/09/11)
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- SUSTAINABLE CHEMICAL PROCESS FOR REDUCTION OF NITRO COMPOUNDS (R-NO2) OR NITROSO COMPOUNDS (R-NO) CONTAINING SULPHONIC OR CARBOXYLIC GROUP INTO CORRESPONDING AMINO COMPOUNDS (R-NH2) WITH INHERENT RECYCLE OF ALL ACIDIC STREAMS GENERATED IN SYNTHESIS
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The process of the present invention creates a sustainable and closed water loop allowing inherent recycles of all liquid streams generated in the process. The liquid streams generated during the process of the invention are inherently recycled completely, making the process of the present invention a zero liquid discharge process which is environmentally friendly and sustainable. This invention further relates to a sustainable chemical process of reduction of R- NO2 or R-NO into corresponding R-NH2 that produces environmentally friendly R-NH2 in good yields and selectivity with large of mother liquor recycle. The process has a wide scope in that it can be applied to a number of molecules.
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Page/Page column 36; 37
(2011/05/06)
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- Selective reduction of 4,4′-dinitrostilbene-2,2′-disulfonic acid catalyzed by supported nano-sized gold with sodium formate as hydrogen source
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Gold nanoparticles supported on four different metal oxides were prepared and applied in the chemoselective reduction of 4,4′-dinitrostilbene-2, 2′-disulfonic acid (DNS). With sodium formate as hydrogen source, > 99% of the DNS was transformed into 4,4′-diaminostilbene-2,2′- disulfonic acid (DSD) without the reduction of olefinic group, which uncovers a clean synthetic approach for useful amino substituted stilbene sulfonic acids.
- Peng, Wenchao,Zhang, Fengbao,Zhang, Guoliang,Liu, Bo,Fan, Xiaobin
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scheme or table
p. 568 - 572
(2012/01/04)
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- Reduction of 4,4′-dinitrostilbene-2,2′-disulfonic acid with hydrogen on raney nickel
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Reduction of 4,4′-dinitrostilbene-2,2′-disulfonic acid with hydrogen in aqueous solution on Raney nickel yields a trisazo compound identical to Direct Yellow K dye.
- Bazanova,Kholodkova,Gostikin
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p. 436 - 440
(2007/10/03)
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