- First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors
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Genetic activation of the bacterial two-component signal transduction system, CpxRA, abolishes the virulence of a number of pathogens in human and murine infection models. Recently, 2,3,4,9-tetrahydro-1H-carbazol-1-amines were shown to activate the CpxRA
- Li, Yangxiong,Gardner, Jessi J.,Fortney, Katherine R.,Leus, Inga V.,Bonifay, Vincent,Zgurskaya, Helen I.,Pletnev, Alexandre A.,Zhang, Sheng,Zhang, Zhong-Yin,Gribble, Gordon W.,Spinola, Stanley M.,Duerfeldt, Adam S.
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supporting information
p. 1836 - 1841
(2019/05/22)
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- HCV INHIBITORS
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The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes compounds useful for the treatment or prophylaxis of dengue fever, yellow fever, West Nile virus, and HCV.
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- HCV INHIBITORS
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The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes compounds useful for the treatment or prophylaxis of dengue fever, yellow fever, West Nile virus, and HCV.
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- HCV INHIBITORS
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The present invention relates to compounds that are useful in the treatment of viruses belonging to Flaviviridae, including flaviviruses, pestiviruses, and hepaciviruses. The invention includes compounds useful for the treatment or prophylaxis of dengue fever, yellow fever, West Nile virus, and HCV.
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- TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE
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The present invention relates to novel compounds of formula (I), that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
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- COMPOSITIONS AND METHODS FOR VIRAL INHIBITION
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The present invention discloses methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including carbazole derivatives useful for viral inhibition.
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Page/Page column 62
(2010/02/11)
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- NOVEL CYCLOALKYL’B! CONDENSED INDOLES
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The present invention relates to compounds of formula (I) that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
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- TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE
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The present invention relates to novel compounds of formula (I) that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
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