- An efficient water-mediated synthetic route for the alkylation of heteroarenes
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An efficient synthetic route has been described for the alkylation of 1H-indole, 1H-benzimidazole, and 1H-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.
- Seyi?Tdanlio?lu, P?nar,Hanashalshahaby, Essam Hamied Ahmed,ünalero?lu, Canan
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p. 1598 - 1610
(2019/01/03)
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- Mannich Bases of 4-Phenyl-3-buten-2-one: A New Class of Antiherpes Agent
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The morpholine Mannich base of 4-phenyl-3-buten-2-one was found to have activity in model infections of herpes simplex.The activity was essentially equivalent to that of disodium phosphonoacetate.This paper presents the biological activity and synthesis o
- Edwards, M.L.,Ritter, H.W.,Stemerick, D.M.,Stewart, K.T.
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p. 431 - 436
(2007/10/02)
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- Antiviral 1-aryl-5-amino-1-penten-3-ones
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Compounds of the formula STR1 wherein R is H, halo, C1-4 alkyl, C1-4 alkoxy, 3,4-methylenedioxy, CF3, NO2, NH2, N(C1-4 alkyl)2, CN, OH, --S(C1-4 alkyl) or --SO2/
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