Enzymatic and nonenzymatic in vitro hydrolysis of 2-methyl-2-[2-(methoxy)phenoxy]-4H-1,3-benzodioxin-4-one and 2-methoxyphenyl O-acetylsalicylate
This paper is concerned with the synthesis and physical properties as well as the enzymatic and nonenzymatic in vitro hydrolysis of the potential aspirin prodrug MR 693 (5) and the salicylic acid prodrug guacetisalum (6). The half-lives of both prodrugs and the amount of aspirin regenerated in each hydrolytic run for 5 have been estimated over a wide range of pH values.
Hundewadt,Senning
p. 545 - 547
(2007/10/02)
Aspirin Prodrugs: 2-Methyl-2-aryloxy-4H-1,3-benzodioxin-4-ones Acting as True Aspirin Prodrugs
This paper is concerned with the synthesis, physical properties and both non-enzymatic and enzymatic in vitro hydrolysis of the title compounds 5.Ten new and two known compounds 5 have been synthesized and characterized.In vitro enzymatic and non-enzymatic hydrolysis of ten compounds 5, including the two known, revealed several of them to behave as true aspirin prodrugs.
Hundewadt, Marianne,Senning, Alexander
p. 746 - 751
(2007/10/02)
More Articles about upstream products of 81674-79-5