SYNTHESIS OF γ-KETOPIMELIC ACID DERIVATIVES BY RHODIUM CARBONYL-CATALYZED HYDROCARBONYLATION OF ACRYLIC ACID DERIVATIVES
The rhodium carbonyl-catalyzed reactions of acrylic acid derivatives (1) with CO in iso-propanol gave selectively γ-ketopimelic acid derivatives (2) in good yields.In the reaction of ethyl acrylate (1b) in iso-propanol-d8, deuterium scrambling in the methylene groups of the products (2b) was observed.