- Method for preparing diacid diester compound under catalysis of deep eutectic solvent
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The invention belongs to the technical field of organic synthesis, and discloses a method for preparing a diacid diester compound through catalysis of a deep eutectic solvent, wherein the deep eutectic solvent takes ammonium salt and ferric salt as hydrogen acceptors, takes p-toluenesulfonic acid as a hydrogen donor, takes diacid or anhydride of the diacid and an alcohol compound as raw materials, and adopts a one-pot method to prepare the diacid diester compound; and under the catalysis of the deep eutectic solvent, the esterification reaction is performed to generate the diester product. The selected deep eutectic solvent has characteristics of environmental protection, easy preparation, cheap components and easy recovery; the preparation method has characteristics of simple operation, simple separation, no water-carrying agent, repeated use of the deep eutectic solvent, and high diester yield.
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Paragraph 0039-0042
(2021/05/19)
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- Esterification of bio-based succinic acid in biphasic systems: Comparison of chemical and biological catalysts
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Different chemical and biological catalysts were screened for the biphasic esterification of aqueous solutions of succinic acid with 1-octanol. Among them, DBSA, Nafion NR-50 and Novozym 435 were found to be the most attractive catalysts. The pH, the temperature and the catalyst concentration had high impacts on the reaction rates. The optimization of the reaction conditions with a single-variable approach for the chemical catalysts and a Response Surface Methodology for the enzyme allowed an increase of the rates by a factor 1.5 for DBSA, 2.3 for Nafion NR-50 and 1.3 for Novozym 435. Real fermentation broths produced from recombinant Escherichia coli could be successfully esterified with conversions up to 93% for DBSA and 70% for Nafion NR-50 and Novozym 435 as catalysts. Finally, DBSA was selected as the cheapest and most active option. Besides, the esters were isolated with a purity of 83% from fermentation broth solutions. DBSA also catalyzed the esterification of succinic acid from fermentation broth with many alcohols creating a broad spectrum of interesting esters. The esters might then be used as end-product, hydrolyzed back to pure succinic acid or hydrogenated.
- Delhomme, Clara,Goh, Serena L.M.,Kuehn, Fritz E.,Weuster-Botz, Dirk
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experimental part
p. 39 - 47
(2012/09/07)
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- Esterification in dry media using ferric perchlorate adsorbed on silica gel
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Adsorption of Fe(ClO4)3(H2O)6 onto chromatographic grade silica gel in the presence of alcohol ( to be used for esterification ) produces a supported reagent, Fe(ClO4)3(ROH)6/SiO2. This reagent, has been found effective for the rapid and high yield of esters, on grinding in the presence of carboxylic acids using pestle and mortar in the solid state.
- Parmar, Anupama,Kaur, Jatinder,Goyal, Rita,Kumar, Baldev,Kumar, Harish
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p. 2821 - 2826
(2007/10/03)
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